This proposal is an application for renewal of support for the Oregon State University Environmental Health Sciences (EHS) Center. EHS Center funding supports EHS Center Investigators, core units, and enrichment programs. The administrative and facilities units are: Director's Office, Administration, Aquatic Toxicology, Bioanalytical Chemistry, Cell Culture, Flow Cytometry, Mass Spectrometry, Nucleic Acids and Proteins, Pathology, Statistics, Technical Services, and Pilot Projects. The units and their facilities' """"""""state-of-the-art"""""""" equipment are utilized by the Director and Center Investigators to conduct research programs at the molecular, cellular, organ, and whole animal levels. The mechanisms of action of a variety of environmental chemicals including polyhalogenated hydrocarbons, pyrrolizidine alkaloids, mycotoxins, halogenated aliphatic hydrocarbons, as well as chemicals capable of formation of biological reactive intermediates and/or induction of biological processes are under investigation in Center Investigators' funded research. The theme of the research mission for the EHS Center is the effects of environmental chemicals on proteins, nucleic acids, and gene expression. The research activities will be devoted largely to (1) interactions of environmental agents with cellular macromolecules, (2) the effects of such agents on gene expression and the properties of gene products, and (3) the analytical tools with which to analyze the environmental agents and the nature of their interaction with macromolecules. The EHS Center Investigators' research interests include bioanalytical chemistry, mass spectrometry instrumentation development, biochemical toxicology, receptor proteins and their mechanisms, growth factors, mechanisms of cellular regulation and death, cellular defense systems, metabolism of environmental chemicals and toxicity, protein and DNA alkylation, gene expression, carcinogenicity mechanisms, modulation ofinitiation and promotion of carcinogenesis and immunotoxicology, and development of statistical methods. The research supported by the Program Project Grant """"""""Toxicology of Environmental Halocarbons"""""""" (NIEHS ES00040) utilizes the core unit resources of the EHS Center, and the annual Pilot Project Program provides opportunities for development of new research activities, capabilities, and initiation of new collaborations. Training and enrichment programs through the affiliated NIEHS Training Grant and the M.S/Ph.D. Toxicology Program include various seminar programs at appropriate levels (academic and public), and workshops, a visiting scientists program, and a liaison with the Extension service toxicology program at OSU. The proposed EHS Center activities are designed to provide a base of support for research that will expand our knowledge about mechanisms of action of certain environmental agents. These efforts should enhance our ability to predict with greater assurance the human health risk due to exposure to these agents.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000210-31
Application #
2684387
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1975-11-01
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
31
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Oregon State University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339
Nix, Cassandra E; Harper, Bryan J; Conner, Cathryn G et al. (2018) Toxicological Assessment of a Lignin Core Nanoparticle Doped with Silver as an Alternative to Conventional Silver Core Nanoparticles. Antibiotics (Basel) 7:
Geier, Mitra C; James Minick, D; Truong, Lisa et al. (2018) Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol 354:115-125
Welch, Barrett; Smit, Ellen; Cardenas, Andres et al. (2018) Trends in urinary arsenic among the U.S. population by drinking water source: Results from the National Health and Nutritional Examinations Survey 2003-2014. Environ Res 162:8-17
Denluck, Lindsay; Wu, Fan; Crandon, Lauren E et al. (2018) Reactive oxygen species generation is likely a driver of copper based nanomaterial toxicity. Environ Sci Nano 5:1473-1481
Ahn, Soyoun; Magaña, Armando Alcazar; Bozarth, Connie et al. (2018) Integrated identification and quantification of cyanobacterial toxins from Pacific Northwest freshwaters by Liquid Chromatography and High-resolution Mass Spectrometry. J Mex Chem Soc 62:
Titaley, Ivan A; Ogba, O Maduka; Chibwe, Leah et al. (2018) Automating data analysis for two-dimensional gas chromatography/time-of-flight mass spectrometry non-targeted analysis of comparative samples. J Chromatogr A 1541:57-62
Geier, Mitra C; Chlebowski, Anna C; Truong, Lisa et al. (2018) Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons. Arch Toxicol 92:571-586
Bugel, Sean M; Tanguay, Robert L (2018) Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish. Toxicol Appl Pharmacol 344:23-34
Gaulke, Christopher A; Rolshoven, John; Wong, Carmen P et al. (2018) Marginal Zinc Deficiency and Environmentally Relevant Concentrations of Arsenic Elicit Combined Effects on the Gut Microbiome. mSphere 3:
Roper, Courtney; Simonich, Staci L Massey; Tanguay, Robert L (2018) Development of a high-throughput in vivo screening platform for particulate matter exposures. Environ Pollut 235:993-1005

Showing the most recent 10 out of 690 publications