Original Goals and Specific AimsThe Aquatic Models Core is a unique facility worldwide, equipped to conduct biomedical research usingtwo of the most powerful aquatic research models -- rainbow trout and zebrafish. It is a self-containedfish hatchery for rearing fish and a histopathology complex for conducting tumor and toxicity studies. Forthe carcinogenesis and toxicity studies, investigators can choose several exposure routes, such aswater-bath exposure of embryos or fry, dietary exposure, or embryo injection. The goal is to facilitate theshort- and long-term experiments of Center investigators in several research cores by: Providing consultation to establish the suitability and feasibility of conducting studies in aquaticmodels; Providing high quality rainbow trout and zebrafish at multiple life stages; Providing technical core support including tank allocations, diet preparation and feeding; Providing assistance in selecting and performing chemical exposures; Providing specific expertise in surgery, necropsy, and histopathological evaluation; Working with the investigators in data acquisition and interpretation.
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