Abstract

The long-term goal of the Oxidative Damage Core is to promote research at Vanderbilt on oxidative damage and the relevance to biological injury. This goal is being pursued by Core investigators directly in their work and through the many collaborations they have established. The Core sponsors a monthly seminar on oxidative damage that serves to promote communication among investigators and provides a helpful forum for students. The seminar series will continue through the next granting period. Members of this Core include Professors R. F. Burk (leader), L. J. Marnett, N. A. Porter, and C. J. Rizzo. These investigators have extensive collaborations both within and outside the institution that enhance oxidative damage research in the Center. Collaborating faculty include Professors L. J. Roberts and J. D. Morrow of Clinical Pharmacology, J. M. May of Endocrinology, J. W. Christman and B. W. Christman of Pulmonary Diseases, M. L. Summar of Genetics, and C. D. Ferris and Dr. K. E. Hill of Gastroenterology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000267-40
Application #
7217347
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
40
Fiscal Year
2006
Total Cost
$14,587
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Wages, Phillip A; Kim, Hye-Young H; Korade, Zeljka et al. (2018) Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol. J Lipid Res 59:1916-1926
Sha, Yan; Minko, Irina G; Malik, Chanchal K et al. (2017) Error-prone replication bypass of the imidazole ring-opened formamidopyrimidine deoxyguanosine adduct. Environ Mol Mutagen 58:182-189
Sugitani, Norie; Voehler, Markus W; Roh, Michelle S et al. (2017) Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates. J Biol Chem 292:16847-16857
Minko, Irina G; Rizzo, Carmelo J; Lloyd, R Stephen (2017) Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical ?-anomer. J Biol Chem 292:18790-18799
Rivara, Matthew B; Yeung, Catherine K; Robinson-Cohen, Cassianne et al. (2017) Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial. Am J Kidney Dis 69:389-399
Yan, H P; Roberts, L J; Davies, S S et al. (2017) Isolevuglandins as a gauge of lipid peroxidation in human tumors. Free Radic Biol Med 106:62-68
Neely, M Diana; Davison, Carrie Ann; Aschner, Michael et al. (2017) From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons. Toxicol Sci 159:366-379
Caito, Samuel W; Aschner, Michael (2016) NAD+ Supplementation Attenuates Methylmercury Dopaminergic and Mitochondrial Toxicity in Caenorhabditis Elegans. Toxicol Sci 151:139-49
Wakeman, Catherine A; Moore, Jessica L; Noto, Michael J et al. (2016) The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction. Nat Commun 7:11951
Sloan, Chantel D; Gebretsadik, Tebeb; Rosas-Salazar, Christian et al. (2016) Seasonal Timing of Infant Bronchiolitis, Apnea and Sudden Unexplained Infant Death. PLoS One 11:e0158521

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