Abstract

Studies conducted by core members focus on a number of enzymes involved in the metabolic activation and detoxication of foreign chemicals, as well as studies on enzymes important in endogenous compound metabolism. The stated goals of the Core are to foster interdisciplinary collaborations, to encourage the flow of technology from basic to more clinical applications, to share equipment and to train the next generation of scientists in this area.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000267-42
Application #
7599200
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
42
Fiscal Year
2008
Total Cost
$55,973
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Wages, Phillip A; Kim, Hye-Young H; Korade, Zeljka et al. (2018) Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol. J Lipid Res 59:1916-1926
Neely, M Diana; Davison, Carrie Ann; Aschner, Michael et al. (2017) From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons. Toxicol Sci 159:366-379
Sha, Yan; Minko, Irina G; Malik, Chanchal K et al. (2017) Error-prone replication bypass of the imidazole ring-opened formamidopyrimidine deoxyguanosine adduct. Environ Mol Mutagen 58:182-189
Sugitani, Norie; Voehler, Markus W; Roh, Michelle S et al. (2017) Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates. J Biol Chem 292:16847-16857
Minko, Irina G; Rizzo, Carmelo J; Lloyd, R Stephen (2017) Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical ?-anomer. J Biol Chem 292:18790-18799
Rivara, Matthew B; Yeung, Catherine K; Robinson-Cohen, Cassianne et al. (2017) Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial. Am J Kidney Dis 69:389-399
Yan, H P; Roberts, L J; Davies, S S et al. (2017) Isolevuglandins as a gauge of lipid peroxidation in human tumors. Free Radic Biol Med 106:62-68
Minko, Irina G; Jacobs, Aaron C; de Leon, Arnie R et al. (2016) Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites. Sci Rep 6:28894
Patra, Amritraj; Su, Yan; Zhang, Qianqian et al. (2016) Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase ?. J Biol Chem 291:14134-45
Deger, Serpil Muge; Hung, Adriana M; Ellis, Charles D et al. (2016) High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients. Clin J Am Soc Nephrol 11:1227-35

Showing the most recent 10 out of 712 publications