Abstract

The objective of the Core is to provide EHSC investigators who complement the University of Rochester with a transgenic mouse facility core. Services include the following: 1) consultation to assist with the design, the establishment and the perpetuation of genetically modified mouse lines, 2) technical assistance with identification and maintenance of mouse lines, and 3) assistance with behavioral testing. The facility appears to be a """"""""full-service"""""""" transgenic mouse core offering a variety of services including generation of transgenic mice by pronuclear DNA microinjection or by gene targeting in ES cells. The facility maintains pedigrees of mouse colonies, offers embryo cryopreservation and rederivation of mouse lines. The Core is staffed by two technical assistants at 90% FTE and 35% FTE and they are supervised by Dr. Stripp (10%).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES001247-28
Application #
6576568
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
28
Fiscal Year
2002
Total Cost
$228,547
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Sobolewski, Marissa; Conrad, Katherine; Marvin, Elena et al. (2018) Endocrine active metals, prenatal stress and enhanced neurobehavioral disruption. Horm Behav 101:36-49
Klocke, Carolyn; Allen, Joshua L; Sobolewski, Marissa et al. (2018) Exposure to fine and ultrafine particulate matter during gestation alters postnatal oligodendrocyte maturation, proliferation capacity, and myelination. Neurotoxicology 65:196-206
McSorley, Emeir M; Yeates, Alison J; Mulhern, Maria S et al. (2018) Associations of maternal immune response with MeHg exposure at 28 weeks' gestation in the Seychelles Child Development Study. Am J Reprod Immunol 80:e13046
Duffney, Parker F; Falsetta, Megan L; Rackow, Ashley R et al. (2018) Key roles for lipid mediators in the adaptive immune response. J Clin Invest 128:2724-2731
Morris-Schaffer, Keith; Sobolewski, Marissa; Allen, Joshua L et al. (2018) Effect of neonatal hyperoxia followed by concentrated ambient ultrafine particle exposure on cumulative learning in C57Bl/6J mice. Neurotoxicology 67:234-244
Willis, Mary D; Jusko, Todd A; Halterman, Jill S et al. (2018) Unconventional natural gas development and pediatric asthma hospitalizations in Pennsylvania. Environ Res 166:402-408
Wahlberg, Karin; Love, Tanzy M; Pineda, Daniela et al. (2018) Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet. Environ Int 115:142-149
Cholette, Jill M; Pietropaoli, Anthony P; Henrichs, Kelly F et al. (2018) Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients. Transfusion 58:1631-1639
Boule, Lisbeth A; Burke, Catherine G; Jin, Guang-Bi et al. (2018) Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome. Sci Rep 8:1826
Lacy, Shannon H; Woeller, Collynn F; Thatcher, Thomas H et al. (2018) Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Anti-Fibrotic Prostaglandins. Am J Respir Cell Mol Biol :

Showing the most recent 10 out of 556 publications