Abstract

B. ENVIRONMENTAL HEALTH IDENTITY AND IMPACT OF RESEARCH BASE B.I. HISTORY OF ENVIRONMENTAL HEALTH SCIENCES AT THE UNIVERSITY OF ROCHESTER Research supported by the Manhattan Project in the 1940s initiated toxicology programs at the University of Rochester. Teams of scientists from different disciplines were assembled in Rochester to determine health effects of uranium, fluorides, mercury and other agents used in the process of nuclear weapons production. These endeavors focused on identifying routes of human exposure, defining mechanisms by which these elements would impair function, assessing vulnerability at different life stages, and developing approaches that could ameliorate toxicant burdens in target tissues. What emerged was an international resource in the toxicology of metals and inorganic elements that remains one of the strengths of the EHSC today.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES001247-40
Application #
8651465
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
40
Fiscal Year
2014
Total Cost
$385,543
Indirect Cost
$136,001

  Institution

Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Wahlberg, Karin; Love, Tanzy M; Pineda, Daniela et al. (2018) Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet. Environ Int 115:142-149
Cholette, Jill M; Pietropaoli, Anthony P; Henrichs, Kelly F et al. (2018) Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients. Transfusion 58:1631-1639
Boule, Lisbeth A; Burke, Catherine G; Jin, Guang-Bi et al. (2018) Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome. Sci Rep 8:1826
Lacy, Shannon H; Woeller, Collynn F; Thatcher, Thomas H et al. (2018) Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Anti-Fibrotic Prostaglandins. Am J Respir Cell Mol Biol :
Lacy, Shannon H; Epa, Amali P; Pollock, Stephen J et al. (2018) Activated human T lymphocytes inhibit TGF?-induced fibroblast to myofibroblast differentiation via prostaglandins D2 and E2. Am J Physiol Lung Cell Mol Physiol 314:L569-L582
Sobolewski, Marissa; Singh, Garima; Schneider, Jay S et al. (2018) Different Behavioral Experiences Produce Distinctive Parallel Changes in, and Correlate With, Frontal Cortex and Hippocampal Global Post-translational Histone Levels. Front Integr Neurosci 12:29
Caito, Samuel W; Jackson, Brian P; Punshon, Tracy et al. (2018) Editor's Highlight: Variation in Methylmercury Metabolism and Elimination Status in Humans Following Fish Consumption. Toxicol Sci 161:443-453
Begolly, Sage; Olschowka, John A; Love, Tanzy et al. (2018) Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion. Glia 66:846-861
Korfmacher, Katrina Smith; Holt, Kathleen D (2018) The Potential for Proactive Housing Inspections to Inform Public Health Interventions. J Public Health Manag Pract 24:444-447
Wong, Elissa L; Lutz, Nina M; Hogan, Victoria A et al. (2018) Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex. Brain Behav Immun 67:257-278

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