Abstract

The Department of Biochemistry of the University of California, Berkeley, has established a Mutagenesis Center under sponsorship of the National Institute of Environmental Health Sciences. This Center unifies the efforts of a number of research groups in the Department working on various aspects of mutagenesis. A growing awareness that damage to the integrity of nucleic acids by environmental mutagens is a major problem in public health has directed many members of the Department towards more practical applications of their basic research. Nine of 18 faculty members participate in the Center. The Mutagenesis Center's main focus is on the following research areas: 1. The detection and characterization of environmental mutagens and carcinogens. 2. The study of mechanisms of mutagenesis. 3. The study of the role of genetic damage in human disease, aging and evolution. 4. The study of DNA repair and other enzymic defenses against DNA damage. 5. The study of basic mechanisms of the dynamic genetic apparatus and chromosomes in higher organisms as related to genetic stability and toxic agent action.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES001896-08
Application #
3102294
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1979-02-08
Project End
1989-01-31
Budget Start
1986-02-01
Budget End
1987-01-31
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Ye, Morgan; Warner, Marcella; Mocarelli, Paolo et al. (2018) Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study. Environ Health 17:22
Engel, Stephanie M; Bradman, Asa; Wolff, Mary S et al. (2016) Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts. Environ Health Perspect 124:822-30
Harley, Kim G; Engel, Stephanie M; Vedar, Michelle G et al. (2016) Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. Environ Health Perspect 124:1084-92
McHale, Cliona M; Smith, Martyn T; Zhang, Luoping (2014) Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to human. Ann N Y Acad Sci 1310:74-83
Chevrier, Jonathan; Warner, Marcella; Gunier, Robert B et al. (2014) Serum dioxin concentrations and thyroid hormone levels in the Seveso Women's Health Study. Am J Epidemiol 180:490-8
Wesselink, Amelia; Warner, Marcella; Samuels, Steven et al. (2014) Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso. Environ Int 63:143-8
Vermeulen, Roel; Zhang, Luoping; Spierenburg, Annejet et al. (2012) Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene. Carcinogenesis 33:1538-41
Zhang, L; Lan, Q; Ji, Z et al. (2012) Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers. Leukemia 26:2494-8
Block, Gladys; Shaikh, Nishat; Jensen, Christopher D et al. (2011) Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1. Am J Clin Nutr 94:929-37
Ren, Xuefeng; Lim, Sophia; Ji, Zhiying et al. (2011) Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. PLoS One 6:e14546

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