Abstract

This research core investigates the role of nutritional factors in modifying the effect of environmental toxicants and carcinogens. It is interdisciplinary in nature. The principal investigators are Drs. Block (core leader), Ames, Bjeldanes, and A. Smith. Research topics broadly cover iron-associated oxidative damage and the role of antioxidants in mitigating such damage (Drs. Block and Ames); the effect of dietary factors in modifying the toxicity of arsenic (Dr. Block and Smith); dietary exposure to pesticides (Dr. Block); dietary intakes and development of assessment and nutrition education tools (Dr. Block) and the effects of indoles on estradiol metabolism (Dr. Bjeldanes). The investigator composition of this core has changed from the last NIEHS grant. Drs. Gold, M. Smith, and Abrams are no longer associated and Drs. Bjeldanes and A. Smith are joining the group. Future research will apparently follow the same lines as described in the """"""""New Findings"""""""" section of this research core but there are few specific future plans described in this section.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES001896-24
Application #
6587595
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
24
Fiscal Year
2002
Total Cost
$228,547
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Type
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Ye, Morgan; Warner, Marcella; Mocarelli, Paolo et al. (2018) Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study. Environ Health 17:22
Harley, Kim G; Engel, Stephanie M; Vedar, Michelle G et al. (2016) Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. Environ Health Perspect 124:1084-92
Engel, Stephanie M; Bradman, Asa; Wolff, Mary S et al. (2016) Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts. Environ Health Perspect 124:822-30
McHale, Cliona M; Smith, Martyn T; Zhang, Luoping (2014) Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to human. Ann N Y Acad Sci 1310:74-83
Chevrier, Jonathan; Warner, Marcella; Gunier, Robert B et al. (2014) Serum dioxin concentrations and thyroid hormone levels in the Seveso Women's Health Study. Am J Epidemiol 180:490-8
Wesselink, Amelia; Warner, Marcella; Samuels, Steven et al. (2014) Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso. Environ Int 63:143-8
Vermeulen, Roel; Zhang, Luoping; Spierenburg, Annejet et al. (2012) Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene. Carcinogenesis 33:1538-41
Zhang, L; Lan, Q; Ji, Z et al. (2012) Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers. Leukemia 26:2494-8
Block, Gladys; Shaikh, Nishat; Jensen, Christopher D et al. (2011) Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1. Am J Clin Nutr 94:929-37
Ren, Xuefeng; Lim, Sophia; Ji, Zhiying et al. (2011) Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. PLoS One 6:e14546

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