Abstract

The purpose of this core is to distribute tester strains and give advice to users of the Ames Salmonella Mutagenesis assay. The Salmonella/liver microsome assay for mutagenicity, developed by Dr. Ames and his students, is a rapid, efficient way to test chemicals for their ability to mutate DNA. It is in use by more than 3000 government, academic, and industrial laboratories throughout the world, including most major pharmaceutical and chemical companies. New Salmonella strains are developed which can be used to diagnose the induction of specific types of gene mutations. The facility houses the storage and maintenance of the over 5000 Salmonella typhomurium and Escherichia coli strains developed in the laboratory and distributes Salmonella strains to any laboratories who require them. About 25 requests are processed each month. In addition, the facility provides training on the use of the assay in the laboratory and through communications. Approximately 15-20 students used the expertise from this Core for their science fair projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES001896-24
Application #
6587600
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
24
Fiscal Year
2002
Total Cost
$228,547
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Type
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Ye, Morgan; Warner, Marcella; Mocarelli, Paolo et al. (2018) Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study. Environ Health 17:22
Engel, Stephanie M; Bradman, Asa; Wolff, Mary S et al. (2016) Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts. Environ Health Perspect 124:822-30
Harley, Kim G; Engel, Stephanie M; Vedar, Michelle G et al. (2016) Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. Environ Health Perspect 124:1084-92
McHale, Cliona M; Smith, Martyn T; Zhang, Luoping (2014) Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to human. Ann N Y Acad Sci 1310:74-83
Chevrier, Jonathan; Warner, Marcella; Gunier, Robert B et al. (2014) Serum dioxin concentrations and thyroid hormone levels in the Seveso Women's Health Study. Am J Epidemiol 180:490-8
Wesselink, Amelia; Warner, Marcella; Samuels, Steven et al. (2014) Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso. Environ Int 63:143-8
Vermeulen, Roel; Zhang, Luoping; Spierenburg, Annejet et al. (2012) Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene. Carcinogenesis 33:1538-41
Zhang, L; Lan, Q; Ji, Z et al. (2012) Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers. Leukemia 26:2494-8
Block, Gladys; Shaikh, Nishat; Jensen, Christopher D et al. (2011) Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1. Am J Clin Nutr 94:929-37
Ren, Xuefeng; Lim, Sophia; Ji, Zhiying et al. (2011) Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. PLoS One 6:e14546

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