The purpose of the Bioanalytical Facilities Core is to provide Center members with state-of-the-art tools and techniques for the characterization and quantification of chemical substances and modifications of cellular molecules such as DNA and protein. The primary objective is to continually increase our capabilities and effectiveness via the following aims: (1) To assist Center members in the purification, identification and quantitation of unknown compounds, synthetic intermediates and products of DNA and protein damage; (2) To maintain a broad range of cutting-edge major analytical instruments to meet the current and future needs of Center members; (3) To keep Center members knowledgable about developments in equipment and methods; (4) To provide expert assistance with method development, experimental design, and data analysis; (5) To guide students and postdoctoral scientists toward analytical excellence and insight.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES002109-26A1
Application #
6874786
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2005-04-01
Project End
2010-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
26
Fiscal Year
2005
Total Cost
$337,692
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Moore, Christopher L; Papa 3rd, Louis J; Shoulders, Matthew D (2018) A Processive Protein Chimera Introduces Mutations across Defined DNA Regions In Vivo. J Am Chem Soc 140:11560-11564
Wang, Xin; Garcia, Carlos T; Gong, Guanyu et al. (2018) Automated Online Solid-Phase Derivatization for Sensitive Quantification of Endogenous S-Nitrosoglutathione and Rapid Capture of Other Low-Molecular-Mass S-Nitrosothiols. Anal Chem 90:1967-1975
Tam, Brooke E; Hao, Yining; Sikes, Hadley D (2018) An examination of critical parameters in hybridization-based epigenotyping using magnetic microparticles. Biotechnol Prog 34:1589-1595
Chan, Cheryl; Pham, Phuong; Dedon, Peter C et al. (2018) Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses. Genome Biol 19:228
Ge, Zhongming; Sheh, Alexander; Feng, Yan et al. (2018) Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses. Sci Rep 8:8014
Li, Weiwei; Chan, Chi-Kong; Liu, Yushuo et al. (2018) Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake. J Agric Food Chem 66:11468-11476
Mannion, Anthony; Shen, Zeli; Fox, James G (2018) Comparative genomics analysis to differentiate metabolic and virulence gene potential in gastric versus enterohepatic Helicobacter species. BMC Genomics 19:830
Yuan, Yifeng; Hutinet, Geoffrey; Valera, Jacqueline Gamboa et al. (2018) Identification of the minimal bacterial 2'-deoxy-7-amido-7-deazaguanine synthesis machinery. Mol Microbiol 110:469-483
Rizzo, Alessandro A; Vassel, Faye-Marie; Chatterjee, Nimrat et al. (2018) Rev7 dimerization is important for assembly and function of the Rev1/Pol? translesion synthesis complex. Proc Natl Acad Sci U S A 115:E8191-E8200
Kulik, Heather J (2018) Large-scale QM/MM free energy simulations of enzyme catalysis reveal the influence of charge transfer. Phys Chem Chem Phys 20:20650-20660

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