The purpose of the Bioanalytical Facilities Core is to provide Center members with state-of-the-art tools and techniques for the characterization and quantification of chemical substances and modifications of cellular molecules such as DNA and protein. The primary objective is to continually increase our capabilities and effectiveness via the following aims: (1) To assist Center members in the purification, identification and quantitation of unknown compounds, synthetic intermediates and products of DNA and protein damage; (2) To maintain a broad range of cutting-edge major analytical instruments to meet the current and future needs of Center members; (3) To keep Center members knowledgable about developments in equipment and methods; (4) To provide expert assistance with method development, experimental design, and data analysis; (5) To guide students and postdoctoral scientists toward analytical excellence and insight.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES002109-30
Application #
7798625
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
30
Fiscal Year
2009
Total Cost
$417,800
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Tajai, Preechaya; Fedeles, Bogdan I; Suriyo, Tawit et al. (2018) An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity. Free Radic Biol Med 116:64-72
Neumann, Wilma; Nolan, Elizabeth M (2018) Evaluation of a reducible disulfide linker for siderophore-mediated delivery of antibiotics. J Biol Inorg Chem 23:1025-1036
Pereira, Gavin C; Sanchez, Laura; Schaughency, Paul M et al. (2018) Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis. Mob DNA 9:35
Wang, Lianrong; Jiang, Susu; Deng, Zixin et al. (2018) DNA phosphorothioate modification - a new multi-functional epigenetic system in bacteria. FEMS Microbiol Rev :
Rothenberg, Daniel A; Taliaferro, J Matthew; Huber, Sabrina M et al. (2018) A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth. iScience 9:367-381
Brody, Yehuda; Kimmerling, Robert J; Maruvka, Yosef E et al. (2018) Quantification of somatic mutation flow across individual cell division events by lineage sequencing. Genome Res 28:1901-1918
Freedman, Adam J E; Peet, Kyle C; Boock, Jason T et al. (2018) Isolation, Development, and Genomic Analysis of Bacillus megaterium SR7 for Growth and Metabolite Production Under Supercritical Carbon Dioxide. Front Microbiol 9:2152
Dudani, Jaideep S; Ibrahim, Maria; Kirkpatrick, Jesse et al. (2018) Classification of prostate cancer using a protease activity nanosensor library. Proc Natl Acad Sci U S A 115:8954-8959
Nakashige, Toshiki G; Bowman, Sarah E J; Zygiel, Emily M et al. (2018) Biophysical Examination of the Calcium-Modulated Nickel-Binding Properties of Human Calprotectin Reveals Conformational Change in the EF-Hand Domains and His3Asp Site. Biochemistry 57:4155-4164
Ganesh, B P; Hall, A; Ayyaswamy, S et al. (2018) Diacylglycerol kinase synthesized by commensal Lactobacillus reuteri diminishes protein kinase C phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium. Mucosal Immunol 11:380-393

Showing the most recent 10 out of 970 publications