Abstract

The Exposure and Dosimetry Modeling Facility Core is directed by Dr. Georgopoulos. Workstations and server clusters that service this facility are located within the EOHSI and the hardware and software used are facilities of the EOHSI Computational Chemodynamics Laboratory (CCL).
The aims of this core are to adapt, improve, and test methods for (1) estimating toxic exposures, including pharmacokinetic modeling of target tissue exposure, (2) assessing biomarkers of exposure, and (3) estimating transport, concentration, and deposition of chemicals, including estimation of inter- and intra-individual variation. The support services offered are (1) assistance with data analysis and (2) assistance with computer modeling. The only tangible evidence of past performance of this Core is contained in four examples, which are critiqued below. Future directions are slated for continued efforts in developing distributed parameter models, and new efforts to incorporate random effects modeling and create food-web models.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
3P30ES005022-15S1
Application #
6587355
Study Section
Project Start
2002-04-15
Project End
2003-03-31
Budget Start
Budget End
Support Year
15
Fiscal Year
2002
Total Cost
$174,086
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Type
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854

  Publications

Tiethof, Angela K; Richardson, Jason R; Hart, Ronald P (2018) Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells. Toxics 6:
Liu, Anna B; Tao, Siyao; Lee, Mao-Jung et al. (2018) Effects of gut microbiota and time of treatment on tissue levels of green tea polyphenols in mice. Biofactors :
Rockafellow-Baldoni, Megan; Spayd, Steven E; Hong, Jun-Yan et al. (2018) Arsenic Exposure and Cancer Risk Reduction with Local Ordinance Requiring Whole-House Dual-Tank Water Treatment Systems. Hum Ecol Risk Assess 24:1256-1267
Jabbar, Shaima; Reuhl, Kenneth; Sarkar, Dipak K (2018) Prenatal alcohol exposure increases the susceptibility to develop aggressive prolactinomas in the pituitary gland. Sci Rep 8:7720
Radbel, Jared; Le-Hoang, Oanh; Vayas, Kinal N et al. (2018) Effect of World Trade Center Dust Exposure and Chronic Intermittent Hypoxia on Macrophage Matrix Metalloproteinase-12 Expression in Mice. Ann Am Thorac Soc 15:S125-S126
Walley, Sabrina N; Roepke, Troy A (2018) Perinatal exposure to endocrine disrupting compounds and the control of feeding behavior-An overview. Horm Behav 101:22-28
Szilagyi, John T; Fussell, Karma C; Wang, Yun et al. (2018) Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol Appl Pharmacol 359:102-107
Li, Wenji; Yang, Hilly; Buckley, Brian et al. (2018) A Novel Triple Stage Ion Trap MS method validated for curcumin pharmacokinetics application: A comparison summary of the latest validated curcumin LC/MS methods. J Pharm Biomed Anal 156:116-124
Cory-Slechta, D A; Allen, J L; Conrad, K et al. (2018) Developmental exposure to low level ambient ultrafine particle air pollution and cognitive dysfunction. Neurotoxicology 69:217-231
Joseph, Laurie B; Composto, Gabriella M; Perez, Roberto M et al. (2018) Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol Lett 293:77-81

Showing the most recent 10 out of 819 publications