Abstract

The global aim of the core is to advance understanding of the mechanisms by which environmental toxicants damage the nervous system.
This aim i s being addressed using contemporary methods in neuroscience, coupled with approaches derived from Center members pursuing other avenues of toxicological research.
The Specific Aims are to, a) elucidate the molecular and cellular changes during development, which underlie the age-specific susceptibilities to neurotoxicants; b) characterize the distinct regions of the nervous system, which exhibit differential sensitivity to environmental toxicants; c) examine the degree to which the developmental and regional sensitivity to toxicants might relate to or serve as models for neurodegenerative diseases or behavioral impairments; and d) obtain correlative molecular, biochemical, morphological and behavioral data to better understand mechanisms of neurotoxicity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES005022-20
Application #
7392680
Study Section
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
20
Fiscal Year
2007
Total Cost
$59,860
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Type
DUNS #
617022384
City
Piscataway
State
NJ
Country
United States
Zip Code
08854

  Publications

Rockafellow-Baldoni, Megan; Spayd, Steven E; Hong, Jun-Yan et al. (2018) Arsenic Exposure and Cancer Risk Reduction with Local Ordinance Requiring Whole-House Dual-Tank Water Treatment Systems. Hum Ecol Risk Assess 24:1256-1267
Jabbar, Shaima; Reuhl, Kenneth; Sarkar, Dipak K (2018) Prenatal alcohol exposure increases the susceptibility to develop aggressive prolactinomas in the pituitary gland. Sci Rep 8:7720
Radbel, Jared; Le-Hoang, Oanh; Vayas, Kinal N et al. (2018) Effect of World Trade Center Dust Exposure and Chronic Intermittent Hypoxia on Macrophage Matrix Metalloproteinase-12 Expression in Mice. Ann Am Thorac Soc 15:S125-S126
Walley, Sabrina N; Roepke, Troy A (2018) Perinatal exposure to endocrine disrupting compounds and the control of feeding behavior-An overview. Horm Behav 101:22-28
Szilagyi, John T; Fussell, Karma C; Wang, Yun et al. (2018) Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol Appl Pharmacol 359:102-107
Li, Wenji; Yang, Hilly; Buckley, Brian et al. (2018) A Novel Triple Stage Ion Trap MS method validated for curcumin pharmacokinetics application: A comparison summary of the latest validated curcumin LC/MS methods. J Pharm Biomed Anal 156:116-124
Cory-Slechta, D A; Allen, J L; Conrad, K et al. (2018) Developmental exposure to low level ambient ultrafine particle air pollution and cognitive dysfunction. Neurotoxicology 69:217-231
Joseph, Laurie B; Composto, Gabriella M; Perez, Roberto M et al. (2018) Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol Lett 293:77-81
Mamounis, Kyle J; Hernandez, Michelle R; Margolies, Nicholas et al. (2018) Interaction of 17?-estradiol and dietary fatty acids on energy and glucose homeostasis in female mice. Nutr Neurosci 21:715-728
Graber, Judith M; Chuang, Connie T; Ward, Carolyn L et al. (2018) Head and Neck Cancer in World Trade Center Responders: A Case Series. J Occup Environ Med 60:e439-e444

Showing the most recent 10 out of 819 publications