Abstract

A wide range of toxicants and drugs exert their biological actions by interfering with cell?cell and intracellular signaling pathways. These agents either mimic a signaling molecule or alter a signaling pathway in such a way as to lead to toxicity. The purpose of the Signal Transduction Core is to bring together investigators with common interests in understanding how xenobiotics modulate cellular signal transduction pathways.
The aim of the Signal Transduction Core is to provide a platform for investigators with common interest in exploring the role of altered cellular signal transduction pathways in toxicant mechanisms. The core is under the direction of Dr. Jeffrey D. Laskin and is co-directed by Dr. Marion K. Gordon. There are 16 core members from several different departments at RWJMS and Rutgers University. The core functions as a mechanism to keep members current with respect to new developments in signal transduction and to provide a forum for meaningful scientific interaction at both the didactic and laboratory levels. The future goals of the core are to develop a toxicoinformatics program to support member research projects, which could benefit from computational assistance. In addition, the core will continue to recruit new investigators, submit grant applications and organize technology-based workshops.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES005022-20
Application #
7392682
Study Section
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
20
Fiscal Year
2007
Total Cost
$86,314
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Type
DUNS #
617022384
City
Piscataway
State
NJ
Country
United States
Zip Code
08854

  Publications

Del Giudice, Marco; Barrett, Emily S; Belsky, Jay et al. (2018) Individual differences in developmental plasticity: A role for early androgens? Psychoneuroendocrinology 90:165-173
Barrett, E S; Hoeger, K M; Sathyanarayana, S et al. (2018) Anogenital distance in newborn daughters of women with polycystic ovary syndrome indicates fetal testosterone exposure. J Dev Orig Health Dis 9:307-314
George, Blessy; Joy, Melanie S; Aleksunes, Lauren M (2018) Urinary protein biomarkers of kidney injury in patients receiving cisplatin chemotherapy. Exp Biol Med (Maywood) 243:272-282
Vail, Gwyndolin; Roepke, Troy A (2018) Membrane-initiated estrogen signaling via Gq-coupled GPCR in the central nervous system. Steroids :
Tiethof, Angela K; Richardson, Jason R; Hart, Ronald P (2018) Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells. Toxics 6:
Liu, Anna B; Tao, Siyao; Lee, Mao-Jung et al. (2018) Effects of gut microbiota and time of treatment on tissue levels of green tea polyphenols in mice. Biofactors :
Rockafellow-Baldoni, Megan; Spayd, Steven E; Hong, Jun-Yan et al. (2018) Arsenic Exposure and Cancer Risk Reduction with Local Ordinance Requiring Whole-House Dual-Tank Water Treatment Systems. Hum Ecol Risk Assess 24:1256-1267
Jabbar, Shaima; Reuhl, Kenneth; Sarkar, Dipak K (2018) Prenatal alcohol exposure increases the susceptibility to develop aggressive prolactinomas in the pituitary gland. Sci Rep 8:7720
Radbel, Jared; Le-Hoang, Oanh; Vayas, Kinal N et al. (2018) Effect of World Trade Center Dust Exposure and Chronic Intermittent Hypoxia on Macrophage Matrix Metalloproteinase-12 Expression in Mice. Ann Am Thorac Soc 15:S125-S126
Walley, Sabrina N; Roepke, Troy A (2018) Perinatal exposure to endocrine disrupting compounds and the control of feeding behavior-An overview. Horm Behav 101:22-28

Showing the most recent 10 out of 819 publications