This core was formerly named the Cancer Core (and before that the Epidemiology and Biometry core). The change in the name and organization of the core to its current one is designed to reflect an expanded interest and effort in reproductive outcomes and statistical genetics. The goal of this research core is to promote and participate in environmental epidemiology research, services, and training related to the rural and agricultural population of Iowa. The core is designed to provide epidemiologic, biostatistical, statistical genetic, and pathology services to Center investigators and to support the Pilot Project Program. To reflect the broadened scope of the core, six new investigators have been added: Drs. Trudy Burns (biostatistics and co-director), Jeff Murray (reproductive outcomes), Paul Romitti (Director of Iowa Birth Defects Registry), Audrey Saftlas (cancer and pregnancy outcomes), Elaine Smith (molecular epidemiology of cancer), and Veronica Vieland (statistical genetics). An additional change in this core is the removal of the environmental engineering component in 1996 to the Environmental Assessment and Control Core, in response to the review for the last renewal, which indicated a poor fit of this component in this Core. A final change is that Dr. Burmeister has moved to the Occupational Health Core, which better reflects his interest, provides statistical expertise to that Core, and facilitates collaboration of these two Cores. The core has completed 34 projects ($27.2 million in funding) and has 38 currently active projects ($82.4 million in funding). Investigators in the core have also produced 168 publications. Future initiatives for this core largely involve its ties to the Health Registry Facility to examine candidate genes and gene-environment (especially pesticides) interactions in relation to reproductive outcomes and cancer, develop better biologic sample collection methods, collect family history information, develop improved questionnaires, develop a sampling and survey unit within the Department of Epidemiology, and improve record linkage of existing databases.
| Meyerholz, David K; Sieren, Jessica C; Beck, Amanda P et al. (2018) Approaches to Evaluate Lung Inflammation in Translational Research. Vet Pathol 55:42-52 |
| Bodduluri, Sandeep; Reinhardt, Joseph M; Hoffman, Eric A et al. (2018) Recent Advances in Computed Tomography Imaging in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc 15:281-289 |
| Haghighi, Babak; D Ellingwood, Nathan; Yin, Youbing et al. (2018) A GPU-based symmetric non-rigid image registration method in human lung. Med Biol Eng Comput 56:355-371 |
| Gergen, Peter J; Mitchell, Herman E; Calatroni, Agustin et al. (2018) Sensitization and Exposure to Pets: The Effect on Asthma Morbidity in the US Population. J Allergy Clin Immunol Pract 6:101-107.e2 |
| Oelsner, Elizabeth C; Smith, Benjamin M; Hoffman, Eric A et al. (2018) Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study. Thorax 73:486-488 |
| Liu, Buyun; Sun, Yangbo; Lehmler, Hans-Joachim et al. (2018) Association between urinary tin concentration and diabetes in nationally representative sample of US adults. J Diabetes 10:977-983 |
| Sodhi, Chhinder P; Wohlford-Lenane, Christine; Yamaguchi, Yukihiro et al. (2018) Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration. Am J Physiol Lung Cell Mol Physiol 314:L17-L31 |
| Parker, Victoria S; Squirewell, Edwin J; Lehmler, Hans-Joachim et al. (2018) Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1. Environ Toxicol Pharmacol 58:196-201 |
| Lee, Mi Kyeong; Carnes, Megan U; Butz, Natasha et al. (2018) Exposures Related to House Dust Microbiota in a U.S. Farming Population. Environ Health Perspect 126:067001 |
| Rosen, Bradley H; Chanson, Marc; Gawenis, Lara R et al. (2018) Animal and model systems for studying cystic fibrosis. J Cyst Fibros 17:S28-S34 |
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