Goals and Aims Our goal is to establish a new Research Cluster to serve as a hub of intellectual activity to build innovative environmental genomics into the EHSRC research portfolio and to serve as a resource that will facilitate the transfer of knowledge, strategy and techniques to junior investigators beginning new programs and established investigators ready to incorporate genomics into existing EHSRC investigations. We will take advantage of successful efforts already in place on our campus with investigators who have a long standing experience of genomics/genetics as well as the capability to provide leadership and guidance. The primary goal in building an environmental genomics research capability is to take advantage of the developments in both laboratory techniques and analytical advances to provide a setting in which investigators can add genetics/genomics to new or ongoing research programs. The initial publication of human genome sequence in 2000 has been followed by a series of ever more startling developments that provide opportunities for individual and population based studies incorporating genetics on a scale that exceeds even the most positive views of just a few years ago. DMA sequencing capabilities, gene expression analysis, proteomics and genotype analysis are now all affordable on a genome scale to even modest size laboratory groups.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES005605-18
Application #
7598997
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
18
Fiscal Year
2008
Total Cost
$33,328
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Bao, Wei; Song, Yiqing; Bertrand, Kimberly A et al. (2018) Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study. J Diabetes 10:373-379
Uwimana, Eric; Ruiz, Patricia; Li, Xueshu et al. (2018) HUMAN CYP2A6, CYP2B6 AND CYP2E1 ATROPSELECTIVELY METABOLIZE POLYCHLORINATED BIPHENYLS TO HYDROXYLATED METABOLITES. Environ Sci Technol :
Hofmann, Jonathan N; Shiels, Meredith S; Friesen, Melissa C et al. (2018) Industrial hog farming is associated with altered circulating immunological markers. Occup Environ Med 75:212-217
Rodriguez, Eric A; Vanle, Brigitte C; Doorn, Jonathan A et al. (2018) Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. Environ Toxicol Pharmacol 62:69-78
Klaren, William D; Vine, David; Vogt, Stefan et al. (2018) Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environ Sci Pollut Res Int 25:16427-16433
Das, Saikat; Oldham, Edward Davis; Lehmler, Hans-Joachim et al. (2018) Tuning the position of head groups by surfactant design in mixed micelles of cationic and carbohydrate surfactants. J Colloid Interface Sci 512:428-438
Liu, Chia-Ying; Parikh, Megha; Bluemke, David A et al. (2018) Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study. J Magn Reson Imaging 47:262-271
Poudel, Barun; Gurung, Prajwal (2018) Allergic asthma: RIPK2 takes the lead. J Leukoc Biol 104:441-443
Uwimana, Eric; Li, Xueshu; Lehmler, Hans-Joachim (2018) Human Liver Microsomes Atropselectively Metabolize 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite. Environ Sci Technol 52:6000-6008
Lynch, Thomas J; Anderson, Preston J; Rotti, Pavana G et al. (2018) Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell 22:653-667.e5

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