Abstract

This Core will focus on the role of genetic susceptibility in toxic responses to environmental agents. Its stated long-range goal is, """"""""to identify and characterize genetic polymorphisms concerning differences in response to environmental agents - responses include tumorigenesis as well as acute and chronic toxicity."""""""" There are six specific aims stated for this Research Core: 1) to elucidate mechanisms of gene expression and regulation through genetic variants; 2) to screen populations and three- generation families for differences in toxic responses; 3) to determine associations between a genetic locus and a phenotypic trait; 4) to understand the molecular basis of a polymorphism; 5) to study the interaction of genes and agents during embryogenesis; and 6) to evaluate the impact of each polymorphism on human health.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES006096-06A1
Application #
6239648
Study Section
Project Start
1997-09-30
Project End
1998-03-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
6
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Cincinnati
Department
Type
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

Giannini, Courtney M; Herrick, Robert L; Buckholz, Jeanette M et al. (2018) Comprehension and perceptions of study participants upon receiving perfluoroalkyl substance exposure biomarker results. Int J Hyg Environ Health 221:1040-1046
Haque, Sulsal-Ul; Niu, Liang; Kuhnell, Damaris et al. (2018) Differential expression and prognostic value of long non-coding RNA in HPV-negative head and neck squamous cell carcinoma. Head Neck 40:1555-1564
Zhang, Hongmei; Yolton, Kimberly; Webster, Glenys M et al. (2018) Prenatal and childhood perfluoroalkyl substances exposures and children's reading skills at ages 5 and 8years. Environ Int 111:224-231
Sharma, Manju; Zhang, Xiang; Huang, Shouxiong (2018) Integrate Imaging Flow Cytometry and Transcriptomic Profiling to Evaluate Altered Endocytic CD1d Trafficking. J Vis Exp :
Vuong, Ann M; Braun, Joseph M; Webster, Glenys M et al. (2018) Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3?years. Environ Int 117:339-347
Pugh, Amanda M; Giannini, Courtney M; Pinney, Susan M et al. (2018) Characteristics and diagnosis of pregnancy and lactation associated breast cancer: Analysis of a self-reported regional registry. Am J Surg 216:809-812
Brunst, Kelly J; Tignor, Nicole; Just, Allan et al. (2018) Cumulative lifetime maternal stress and epigenome-wide placental DNA methylation in the PRISM cohort. Epigenetics 13:665-681
Alexander, Jacqueline; Teague, April M; Chen, Jing et al. (2018) Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy. PLoS One 13:e0190698
Kim, Dasom; Chen, Zi; Zhou, Lin-Fu et al. (2018) Air pollutants and early origins of respiratory diseases. Chronic Dis Transl Med 4:75-94
Brunst, Kelly J; Sanchez-Guerra, Marco; Chiu, Yueh-Hsiu Mathilda et al. (2018) Prenatal particulate matter exposure and mitochondrial dysfunction at the maternal-fetal interface: Effect modification by maternal lifetime trauma and child sex. Environ Int 112:49-58

Showing the most recent 10 out of 979 publications