Abstract

This Core will focus on the role of genetic susceptibility in toxic responses to environmental agents. Its stated long-range goal is, """"""""to identify and characterize genetic polymorphisms concerning differences in response to environmental agents - responses include tumorigenesis as well as acute and chronic toxicity."""""""" There are six specific aims stated for this Research Core: 1) to elucidate mechanisms of gene expression and regulation through genetic variants; 2) to screen populations and three- generation families for differences in toxic responses; 3) to determine associations between a genetic locus and a phenotypic trait; 4) to understand the molecular basis of a polymorphism; 5) to study the interaction of genes and agents during embryogenesis; and 6) to evaluate the impact of each polymorphism on human health.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES006096-08
Application #
6106358
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Cincinnati
Department
Type
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

Isiugo, Kelechi; Newman, Nicholas; Jandarov, Roman et al. (2018) Assessing the accuracy of commercially available gas sensors for the measurement of ambient ozone and nitrogen dioxide. J Occup Environ Hyg 15:782-791
Li, Tao; Hu, Rong; Chen, Zi et al. (2018) Fine particulate matter (PM2.5): The culprit for chronic lung diseases in China. Chronic Dis Transl Med 4:176-186
Zhang, Xue; Biagini Myers, Jocelyn M; Burleson, J D et al. (2018) Nasal DNA methylation is associated with childhood asthma. Epigenomics 10:629-641
Haynes, Erin N; Sucharew, Heidi; Hilbert, Timothy J et al. (2018) Impact of air manganese on child neurodevelopment in East Liverpool, Ohio. Neurotoxicology 64:94-102
Bermúdez, Mei-Ling; Skelton, Matthew R; Genter, Mary Beth (2018) Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease. Mol Genet Metab 125:305-313
Reigle, Beverly S; Zhang, Bin (2018) Women's Rehabilitation Experiences Following Breast Cancer Surgery. Rehabil Nurs 43:195-200
Whitt, Jordan; Woo, Vivienne; Lee, Patrick et al. (2018) Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology 155:501-513
Uno, Shigeyuki; Nebert, Daniel W; Makishima, Makoto (2018) Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. Food Chem Toxicol 113:73-82
Vuong, Ann M; Yolton, Kimberly; Poston, Kendra L et al. (2018) Childhood polybrominated diphenyl ether (PBDE) exposure and executive function in children in the HOME Study. Int J Hyg Environ Health 221:87-94
Lee, Alison G; Le Grand, Blake; Hsu, Hsiao-Hsien Leon et al. (2018) Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects. Respir Res 19:76

Showing the most recent 10 out of 979 publications