Abstract

The Molecular Genetics Core provides NIEHS Center investigators a variety of services and technical support in the areas of recombinant DNA technology, gene expression analysis and molecular genetics. While recombinant DNA technology remains an essential part of many of the research projects in the Center, there is an increasing demand for more sophisticated support for site-directed mutagenesis, bacterial and eukaryotic expression constructs, and construction of plasmids to create transgenic and knockout mice by Center investigators. In addition, the Molecular Genetics Core has developed facilities for expression analysis using both Affymetrix GeneChips as well as custom microarray technologies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES006676-11
Application #
6872711
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2005-04-01
Project End
2010-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
11
Fiscal Year
2005
Total Cost
$396,873
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Yoon, Jung-Hoon; Hodge, Richard P; Hackfeld, Linda C et al. (2018) Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct. J Biol Chem 293:2949-2958
Prochaska, John D; Buschmann, Robert N; Jupiter, Daniel et al. (2018) Subjective neighborhood assessment and physical inactivity: An examination of neighborhood-level variance. Prev Med 111:336-341
Tian, Bing; Yang, Jun; Zhao, Yingxin et al. (2018) Central Role of the NF-?B Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-Induced Airway Inflammation. J Virol 92:
Speidel, Jordan T; Xu, Meixiang; Abdel-Rahman, Sherif Z (2018) Bisphenol A (BPA) and bisphenol S (BPS) alter the promoter activity of the ABCB1 gene encoding P-glycoprotein in the human placenta in a haplotype-dependent manner. Toxicol Appl Pharmacol 359:47-54
Speidel, Jordan T; Xu, Meixiang; Abdel-Rahman, Sherif Z (2018) Promoter Haplotypes of the ABCB1 Gene Encoding the P-Glycoprotein Differentially Affect Its Promoter Activity by Altering Transcription Factor Binding. DNA Cell Biol 37:973-981
Lu, Lee-Jane W; Chen, Nai-Wei; Nayeem, Fatima et al. (2018) Novel effects of phytoestrogenic soy isoflavones on serum calcium and chloride in premenopausal women: A 2-year double-blind, randomized, placebo-controlled study. Clin Nutr 37:1862-1870
Tian, Bing; Liu, Zhiqing; Yang, Jun et al. (2018) Selective Antagonists of the Bronchiolar Epithelial NF-?B-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation. Cell Rep 23:1138-1151
Ochoa, Lorenzo F; Kholodnykh, Alexander; Villarreal, Paula et al. (2018) Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing. Sci Rep 8:13348
Hao, Wenjing; Qi, Tianyang; Pan, Lang et al. (2018) Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA. Redox Biol 18:43-53
Shoeb, Mohammad; Zhang, Min; Xiao, Tianlin et al. (2018) Amelioration of Endotoxin-Induced Inflammatory Toxic Response by a Metal Chelator in Rat Eyes. Invest Ophthalmol Vis Sci 59:31-38

Showing the most recent 10 out of 601 publications