Abstract

The overall objective of the Genomics Facility Core (GFC) is to provide microarray analysis and technology to? SWEHSC members, Arizona Cancer Center (AZCC) members, and the wider research community. The Core's? purpose is to consolidate resources and expertise, and provide complete microarray support in order to minimize? cost and effort to researchers who want to use microarrays in their investigations. To fulfill this purpose, the? Core has the following Specific Aims:? 1. Provide a complete microarray service offering, RNA quality control, target preparation, hybridization,? scanning, quantitation, data analysis, and independent confirmation of results.? 2. Facilitate use of microarray technology by providing consultation on experimental design, sample? preparation, experimental protocols, and performing data analysis.? 3. Provide users with access to complementary microarray platforms: low cost microarrays manufactured? on-site and commercially available Affymetrix GeneChips.? 4. Test new microarray technology as it emerges and update the GFC's technology and services as? appropriate.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES006694-11A1
Application #
7027883
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2006-04-01
Project End
2011-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
11
Fiscal Year
2006
Total Cost
$151,329
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Dodson, Matthew; Liu, Pengfei; Jiang, Tao et al. (2018) Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction. Mol Cell Biol :
Griggs, Chanel A; Malm, Scott W; Jaime-Frias, Rosa et al. (2018) Valproic acid disrupts the oscillatory expression of core circadian rhythm transcription factors. Toxicol Appl Pharmacol 339:110-120
Toth, Erica L; Li, Hui; Dzierlenga, Anika L et al. (2018) Gene-by-Environment Interaction of Bcrp-/- and Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition. Drug Metab Dispos 46:1478-1486
Malm, S W; Amouzougan, E A; Klimecki, W T (2018) Fetal bovine serum induces sustained, but reversible, epithelial-mesenchymal transition in the BEAS-2B cell line. Toxicol In Vitro 50:383-390
Rojo de la Vega, Montserrat; Zhang, Donna D; Wondrak, Georg T (2018) Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin. Front Pharmacol 9:287
Harris, Alondra P; Ismail, Kareem A; Nunez, Martha et al. (2018) Trichloroethylene perturbs HNF4a expression and activity in the developing chick heart. Toxicol Lett 285:113-120
Dzierlenga, Anika L; Cherrington, Nathan J (2018) Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis. J Biochem Mol Toxicol 32:e22035
Yellowhair, Monica; Romanotto, Michelle R; Stearns, Diane M et al. (2018) Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38
Wales, Jessica A; Chen, Cheng-Yu; Breci, Linda et al. (2018) Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase. J Biol Chem 293:1850-1864
Bime, Christian; Fiero, Mallorie; Lu, Zhenqiang et al. (2017) High Positive End-Expiratory Pressure Is Associated with Improved Survival in Obese Patients with Acute Respiratory Distress Syndrome. Am J Med 130:207-213

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