Abstract

The overall objective of this Core is to provide state-of-the-art capabilities for identifying and characterizing genetic associations to environmentally initiated disease. The core identified three aims that focus on the development of instrumentation for multi-user access to high throughput DNA sequencing and automated genotyping services, provision of consultation on the adaptation of molecular approaches to individual research programs, and integration of functional genomics capabilities (real-time quantitative PCR and DNA chip expression array technologies).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007033-08
Application #
6577782
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
$73,467
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Khan, Burhan A; Robinson, Renee; Fohner, Alison E et al. (2018) Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People. Clin Transl Sci 11:312-321
Tanner, Julie-Anne; Zhu, Andy Z; Claw, Katrina G et al. (2018) Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism. Pharmacogenet Genomics 28:7-16
Monteiro, Maria B; Ramm, Susanne; Chandrasekaran, Vidya et al. (2018) A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. J Am Soc Nephrol 29:2820-2833
Miller, Kristin A; Spalt, Elizabeth W; Gassett, Amanda J et al. (2018) Estimating ambient-origin PM2.5 exposure for epidemiology: observations, prediction, and validation using personal sampling in the Multi-Ethnic Study of Atherosclerosis. J Expo Sci Environ Epidemiol :
Wallace, James C; Youngblood, Jessica E; Port, Jesse A et al. (2018) Variability in metagenomic samples from the Puget Sound: Relationship to temporal and anthropogenic impacts. PLoS One 13:e0192412
Suter, Megan K; Karr, Catherine J; John-Stewart, Grace C et al. (2018) Implications of Combined Exposure to Household Air Pollution and HIV on Neurocognition in Children. Int J Environ Res Public Health 15:
Hooper, Laura G; Kaufman, Joel D (2018) Ambient Air Pollution and Clinical Implications for Susceptible Populations. Ann Am Thorac Soc 15:S64-S68
Wong, Timothy; Wang, Zhican; Chapron, Brian D et al. (2018) Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans. Drug Metab Dispos 46:367-379
Riley, Erin A; Carpenter, Emily E; Ramsay, Joemy et al. (2018) Evaluation of 1-Nitropyrene as a Surrogate Measure for Diesel Exhaust. Ann Work Expo Health 62:339-350
Cheng, Sunny Lihua; Li, Xueshu; Lehmler, Hans-Joachim et al. (2018) Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis. Toxicol Sci 166:269-287

Showing the most recent 10 out of 711 publications