Abstract

The Reproductive and Developmental Toxicology Research Core consists of seven established/junior investigators and five affiliate investigators representing a variety of disciplines including environmental health, pediatrics, pharmacology, pathology, epidemiology, and comparative medicine. The topic of this core is defined to cover reproductive events leading to gamete formation, fertilization, pre- and post-implantation and development, postnatal development, and the overall process of aging.
The specific aims of the core are: 1) nurture individual and collaborative research to understand molecular and biochemical mechanisms of reproductive and developmental toxicity; 2) foster research to identify factors affecting individual susceptibility to these adverse endpoints; 3) develop biomarkers for these toxic effects that can be used in molecular epidemiology studies; and 4) promote research on women?s and children?s health problems.
These aims will continue for years 6 through 10. This Core has used and will continue to use a variety of mechanisms to reach its goals. This has included group meetings, seminar speakers, visiting scientists, pilot projects, and support for sample analyses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007033-08
Application #
6577779
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
$73,467
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Dempsey, Joseph; Zhang, Angela; Cui, Julia Yue (2018) Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice. BMC Genomics 19:834
Rooney, James P K; Woods, Nancy F; Martin, Michael D et al. (2018) Genetic polymorphisms of GRIN2A and GRIN2B modify the neurobehavioral effects of low-level lead exposure in children. Environ Res 165:1-10
Chang, Yu-Chi; Cole, Toby B; Costa, Lucio G (2018) Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice. Part Fibre Toxicol 15:18
Li, Cindy Yanfei; Dempsey, Joseph L; Wang, Dongfang et al. (2018) PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice. Drug Metab Dispos 46:1226-1240
Khan, Burhan A; Robinson, Renee; Fohner, Alison E et al. (2018) Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People. Clin Transl Sci 11:312-321
Tanner, Julie-Anne; Zhu, Andy Z; Claw, Katrina G et al. (2018) Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism. Pharmacogenet Genomics 28:7-16
Monteiro, Maria B; Ramm, Susanne; Chandrasekaran, Vidya et al. (2018) A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. J Am Soc Nephrol 29:2820-2833
Miller, Kristin A; Spalt, Elizabeth W; Gassett, Amanda J et al. (2018) Estimating ambient-origin PM2.5 exposure for epidemiology: observations, prediction, and validation using personal sampling in the Multi-Ethnic Study of Atherosclerosis. J Expo Sci Environ Epidemiol :
Wallace, James C; Youngblood, Jessica E; Port, Jesse A et al. (2018) Variability in metagenomic samples from the Puget Sound: Relationship to temporal and anthropogenic impacts. PLoS One 13:e0192412
Suter, Megan K; Karr, Catherine J; John-Stewart, Grace C et al. (2018) Implications of Combined Exposure to Household Air Pollution and HIV on Neurocognition in Children. Int J Environ Res Public Health 15:

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