Abstract

The Transgenic Animals Core provides CRED members the specialized equipment and technical assistant needed in the development of transgenic mouse models via DNA microinjection. In addition, this Core offers assistance in deriving pathogen-free mouse strains via embryo transfer. The Core is currently developing procedures for embryo freezing and storage. Plans include the development of a transgene plasmid library to facilitate member development of transgenic mouse models and the introduction of additional mouse strains as egg donors for DNA microinjection. The Core tentatively intends to offer assistance in generating mouse embryonic stem cell derived knock-out, knock-in, and conditional knock-out mice in the next five-year period. A new focus of the Core will be the production of transgenic fish in collaboration Dr. Nairn (Director, RC2), Dr. Bailey of the Marine/Freshwater Biomedical Sciences Center at Oregon State University, and Dr. Richard Winn at the University of Georgia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007784-07
Application #
6590003
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
7
Fiscal Year
2002
Total Cost
$73,467
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Han, Ying; Rand, Kristin A; Hazelett, Dennis J et al. (2016) Prostate Cancer Susceptibility in Men of African Ancestry at 8q24. J Natl Cancer Inst 108:
Rand, Kristin A; Rohland, Nadin; Tandon, Arti et al. (2016) Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk. Hum Mol Genet 25:371-81
Rand, Kristin A; Song, Chi; Dean, Eric et al. (2016) A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci. Cancer Epidemiol Biomarkers Prev 25:1609-1618
Takata, Kei-Ichi; Tomida, Junya; Reh, Shelley et al. (2015) Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ? (POLN). J Biol Chem 290:24278-93
Han, Ying; Hazelett, Dennis J; Wiklund, Fredrik et al. (2015) Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions. Hum Mol Genet 24:5603-18
Nowinski, Sara M; Solmonson, Ashley; Rundhaug, Joyce E et al. (2015) Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis. Nat Commun 6:8137
Cifarelli, V; Hursting, S D (2015) Obesity, Diabetes and Cancer: A Mechanistic Perspective. Int J Diabetol Vasc Dis Res 2015:
Rao, Dharanija; Macias, Everardo; Carbajal, Steve et al. (2015) Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. Mol Carcinog 54:121-33
Han, Ying; Signorello, Lisa B; Strom, Sara S et al. (2015) Generalizability of established prostate cancer risk variants in men of African ancestry. Int J Cancer 136:1210-7
Perez, Carlos J; Rundhaug, Joyce E; Johnson, David G et al. (2014) Slug expression in mouse skin and skin tumors is not regulated by p53. J Invest Dermatol 134:566-568

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