Abstract

The purpose of the Toxicokinetic Susceptibility Research Core (TSRC) is to foster collaboration and sharing of ideas, data and methods among the members in a manner that enhances existing Center projects and motivates proposals for future studies. The specific objectives of the TSRC are to: 1) Support and expand collaborative research involving the following loci: i) biomarkers of exposure and effect, ii) biologically-based modeling, and iii) hepatotoxicity, as well as research involving two or more of these areas. 2) Establish effective mechanisms for sharing ideas within and among focus groups and expanding Core membership to other relevant scientists. 3) Increase interactions with other Research and Facility Cores to foster application of sound toxicokinetic principles in study designs of Center members and affiliates.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES010126-09
Application #
7799330
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
9
Fiscal Year
2009
Total Cost
$35,212
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Barrington, William T; Wulfridge, Phillip; Wells, Ann E et al. (2018) Improving Metabolic Health Through Precision Dietetics in Mice. Genetics 208:399-417
Cui, Tianqu; Zeng, Zhexi; Dos Santos, Erickson O et al. (2018) Development of a hydrophilic interaction liquid chromatography (HILIC) method for the chemical characterization of water-soluble isoprene epoxydiol (IEPOX)-derived secondary organic aerosol. Environ Sci Process Impacts 20:1524-1536
Robbins, Zachary; Bodnar, Wanda; Zhang, Zhenfa et al. (2018) Trisaminohexyl isocyanurate, a urinary biomarker of HDI isocyanurate exposure. J Chromatogr B Analyt Technol Biomed Life Sci 1076:117-129
Pietryk, Edward W; Clement, Kiristin; Elnagheeb, Marwa et al. (2018) Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme. Reprod Toxicol 78:9-19
Marks, Daniel L; Blackmon, Richard L; Oldenburg, Amy L (2018) Diffusion tensor optical coherence tomography. Phys Med Biol 63:025007
Sarnowski, Chloé; Kavousi, Maryam; Isaacs, Steve et al. (2018) Genetic variants associated with earlier age at menopause increase the risk of cardiovascular events in women. Menopause 25:451-457
Kelley, Dannielle E; Boynton, Marcella H; Noar, Seth M et al. (2018) Effective Message Elements for Disclosures About Chemicals in Cigarette Smoke. Nicotine Tob Res 20:1047-1054
Doherty, Brett T; Hoffman, Kate; Keil, Alexander P et al. (2018) Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study. Environ Res 169:33-40
Isom, Daniel G; Page, Stephani C; Collins, Leonard B et al. (2018) Coordinated regulation of intracellular pH by two glucose-sensing pathways in yeast. J Biol Chem 293:2318-2329
Wang, Ting; Wang, Xiaofei; Zhou, Haibo et al. (2018) Auxiliary variable-enriched biomarker-stratified design. Stat Med 37:4610-4635

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