This is a revised application to establish a NIEHS Center in Environmental Health Sciences at the University of Pennsylvania. The Center will hold the title: """"""""Center for Excellence in Environmental Toxicology (CEET)"""""""". It will be the single entity that coordinates, facilitates, synergizes and integrates all environmentally related health research and outreach at the University. The CEET has identified 50 faculty members in 16 Departments from 5 Schools as Center members. These members are dedicated to the CEET mission, which is: to improve the health of the public living in urban environments with an aging industrial infrastructure, through basic, translational and clinical research, and outreach. The investigators will relate environmental exposures, to molecular/cellular effects, to health outcomes, with the vision that diseases with environmental etiology can be largely eliminated by effective prevention or intervention strategies and/or changes in environmental policy. The mission will be accomplished via four integrated Research Cores, three Facility Cores, and a vibrant Community Outreach and Education Program (COEP). The Research Cores are led by investigators with international reputations. These Cores are in Oxidative Stress and Oxidative Stress Injury (co-Directors: Drs. Blair and Ischiropoulos), Endocrine and Reproduction Disruption (co-Directors: Drs. Strauss and Manson), Lung and Airway Disease (co-Directors: Drs. Panettieri and Albelda), and Genes and the Environment (co-Directors: Drs. Rebbeck and Whitehead). These Cores address environmental health issues important to our urban region. Adverse reproductive and pregnancy outcomes, developmental disorders, and diseases of the lung and airway are common, and are addressed in the organ-based Cores. The Cores in Oxidative Stress and Genes in the Environment will elucidate key mechanisms by which environmental exposures can lead to toxicity in these and other organ systems leading to an integrated Center structure. The Facility Cores will be in Toxicogenomics, Toxicoproteomics and Biomarkers, and will provide investigators with services that would otherwise be unattainable and will propel investigators into the new era of predictive toxicology. The COEP will disseminate the research findings and utilize the expertise of CEET investigators: to enhance K-16 education in environmental health; to conduct community outreach in four environmentally challenged Southeastern Pennsylvania communities, and to enrich the education of health care professionals. The COEP has forged relationships with community partners for outreach. The COEP goal will be to reduce the risk of harmful exposures and improve the public health of vulnerable populations within these communities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
1P30ES013508-01A1
Application #
7019711
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
2006-04-13
Project End
2010-03-31
Budget Start
2006-04-13
Budget End
2007-03-31
Support Year
1
Fiscal Year
2006
Total Cost
$799,953
Indirect Cost
Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Furman, Ran; Lee, Jin V; Axelsen, Paul H (2018) Analysis of eicosanoid oxidation products in Alzheimer brain by LC-MS with uniformly 13C-labeled internal standards. Free Radic Biol Med 118:108-118
Zacharias, William J; Frank, David B; Zepp, Jarod A et al. (2018) Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature 555:251-255
Piette, Elizabeth R; Moore, Jason H (2018) Improving machine learning reproducibility in genetic association studies with proportional instance cross validation (PICV). BioData Min 11:6
Fisher, Aron B; Vasquez-Medina, Jose P; Dodia, Chandra et al. (2018) Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes. Redox Biol 14:41-46
Beaulieu-Jones, Brett K; Lavage, Daniel R; Snyder, John W et al. (2018) Characterizing and Managing Missing Structured Data in Electronic Health Records: Data Analysis. JMIR Med Inform 6:e11
Boland, Mary Regina; Kraus, Marc S; Dziuk, Eddie et al. (2018) Cardiovascular Disease Risk Varies by Birth Month in Canines. Sci Rep 8:7130
Beaumont, Robin N; Warrington, Nicole M; Cavadino, Alana et al. (2018) Genome-wide association study of offspring birth weight in 86?577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet 27:742-756
Cui, Naixue; Deatrick, Janet A; Liu, Jianghong (2018) Maternal and paternal physical abuse: Unique and joint associations with child behavioral problems. Child Abuse Negl 76:524-532
Romero, Freddy; Hong, Xu; Shah, Dilip et al. (2018) Lipid Synthesis Is Required to Resolve Endoplasmic Reticulum Stress and Limit Fibrotic Responses in the Lung. Am J Respir Cell Mol Biol 59:225-236
Barrett, Emily S; Vitek, Wendy; Mbowe, Omar et al. (2018) Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Hum Reprod 33:1757-1766

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