Abstract

The dual mission of the Integrative Health Sciences Facility Core (IHSFC) is to (1) provide Infrastructural support for the translation of basic science observations into human studies and trials with the ultimate aim of detecting, preventing and/or managing diseases induced or exacerbated by environmental exposures, and (11) 'back translate' environmental health questions derived from the community into testable hypotheses for human studies (Figure 1). Current and prospective investigators interested in extending their research into human studies may access the IHSFC via the CEET web site or through the IHSFC director's office. Community-based questions relating to healthy individuals or patients will be channeled through the Community Outreach and Education Core (COEC) and framed as scientifically relevant queries to be addressed by CEET investigators using the resources of the IHSFC. A focus is on predicting who is at risk of expo- sure, who is at risk for disease, and who will respond to treatment with an emphasis on PERsonalized Environmental/health Medicine (PEREM). Ultimately the investigator-or community-derived environmental health science (EHS) questions will be translated into: novel diagnostics; intervention or prevention strategies; new therapeutic targets; and/or improved environmental or public health education and policy in communities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES013508-06
Application #
8248247
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2011-04-01
Project End
2015-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
6
Fiscal Year
2011
Total Cost
$244,581
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Xin, Frances; Fischer, Erin; Krapp, Christopher et al. (2018) Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction. Horm Behav 102:93-104
Knijnenburg, Theo A; Wang, Linghua; Zimmermann, Michael T et al. (2018) Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. Cell Rep 23:239-254.e6
Blundell, Cassidy; Yi, Yoon-Suk; Ma, Lin et al. (2018) Placental Drug Transport-on-a-Chip: A Microengineered In Vitro Model of Transporter-Mediated Drug Efflux in the Human Placental Barrier. Adv Healthc Mater 7:
Whelan, Kelly A; Muir, Amanda B; Nakagawa, Hiroshi (2018) Esophageal 3D Culture Systems as Modeling Tools in Esophageal Epithelial Pathobiology and Personalized Medicine. Cell Mol Gastroenterol Hepatol 5:461-478
Winterbottom, Christopher J; Shah, Rupal J; Patterson, Karen C et al. (2018) Exposure to Ambient Particulate Matter Is Associated With Accelerated Functional Decline in Idiopathic Pulmonary Fibrosis. Chest 153:1221-1228
Chikara, Shireen; Mamidi, Sujan; Sreedasyam, Avinash et al. (2018) Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice. Cancer Prev Res (Phila) 11:27-37
Friedman, Elliot S; Bittinger, Kyle; Esipova, Tatiana V et al. (2018) Microbes vs. chemistry in the origin of the anaerobic gut lumen. Proc Natl Acad Sci U S A 115:4170-4175
Sullivan, John; Croisant, Sharon; Howarth, Marilyn et al. (2018) Implications of the GC-HARMS Fishermen's Citizen Science Network: Issues Raised, Lessons Learned, and Next Steps for the Network and Citizen Science. New Solut :1048291118810871
Shastri, Nishita; Tsai, Yu-Chen; Hile, Suzanne et al. (2018) Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition. Mol Cell 72:222-238.e11
Pietrofesa, Ralph A; Chatterjee, Shampa; Park, Kyewon et al. (2018) Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner. Antioxidants (Basel) 7:

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