Abstract

The Vision Research Group housed in the Jules Stein Eye Institute (JSEI) consists of 16 vision scientists with independent NEI funding (including 1 MERIT, 15 R01's, 1 U10 and 2 R03's). Two are participating investigators. Four of the investigators held MERIT awards during the last award period. The objective of the Core Grant for Vision Research at the JSEI is to provide a critically needed infrastructure to support the research of this talented group of scientists, whose common goal is to increase basic knowledge of the visual system and its disorders. To achieve this objective, personnel and instrument support facilities will be organized according to the following modules: (1) Biochemistry; (2) Microscopy and Imaging; (3) Machine Shop, and (4) Molecular Biology. These modules provide instrumentation commonly used by multiple laboratories, and are essential to the success of the individual projects. Purchase of the state-of-the-art instruments in the modules was made possible by the generosity of the JSEI, and additional support is requested only to maintain these existing modules through instrument service contracts, and to provide the necessary personnel support for user training and routine maintenance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY000331-41
Application #
7189854
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Chin, Hemin R
Project Start
1997-03-01
Project End
2009-02-28
Budget Start
2007-03-01
Budget End
2008-02-29
Support Year
41
Fiscal Year
2007
Total Cost
$481,963
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Peng, Yingqian; Baulier, Edouard; Ke, Yifeng et al. (2018) Human embryonic stem cells extracellular vesicles and their effects on immortalized human retinal Müller cells. PLoS One 13:e0194004
Clark, Robert A; Demer, Joseph L (2018) The Globe's Eccentric Rotational Axis: Why Medial Rectus Surgery Is More Potent than Lateral Rectus Surgery. Ophthalmology 125:1234-1238
Van Eps, Ned; Altenbach, Christian; Caro, Lydia N et al. (2018) Gi- and Gs-coupled GPCRs show different modes of G-protein binding. Proc Natl Acad Sci U S A 115:2383-2388
Shin, Andrew; Park, Joseph; Demer, Joseph L (2018) Opto-mechanical characterization of sclera by polarization sensitive optical coherence tomography. J Biomech 72:173-179
Volland, Stefanie; Williams, David S (2018) Preservation of Photoreceptor Nanostructure for Electron Tomography Using Transcardiac Perfusion Followed by High-Pressure Freezing and Freeze-Substitution. Adv Exp Med Biol 1074:603-607
Kintzer, Alexander F; Green, Evan M; Dominik, Pawel K et al. (2018) Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc Natl Acad Sci U S A 115:E9095-E9104
Bergdoll, Lucie A; Lerch, Michael T; Patrick, John W et al. (2018) Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1. Proc Natl Acad Sci U S A 115:E172-E179
Vahedi, Farnoosh; Chung, Doug D; Gee, Katherine M et al. (2018) Epithelial Recurrent Erosion Dystrophy Secondary to COL17A1 c.3156C>T Mutation in a Non-white Family. Cornea 37:909-911
Zhang, Xiang-Mei; Hashimoto, Takao; Tang, Ronald et al. (2018) Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. Sci Rep 8:6823
Chaudhuri, Zia; Demer, Joseph L (2018) Long-term Surgical Outcomes in the Sagging Eye Syndrome. Strabismus 26:6-10

Showing the most recent 10 out of 289 publications