Abstract

The goal of the Imaging and Electrophysiology Core Module (IECM) is to provide shared resources to the investigators of the vision research center (VRC) for imaging and electrophysiological recording. The core instruments of the IECM support imaging (confocal and two-photon) and electrophysiology (patch clamp in vitro, simultaneous with 2P imaging) as well as high density multiunit retinal recording using a multi-electrode array. The IECM also subsidizes the use of two confocal microscopes and a cSLO-OCT system for imaging of retina in vivo in canine. The IECM offers full technical assistance through trained personnel to facilitate use of the instruements. The IECM also provides hub of for collaborative work among members of the VRC by enabling multidisciplinary projects about the normal structure and function of the visual system and its pathological alterations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001583-44
Application #
9549059
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
44
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Collins, David W; Gudiseva, Harini V; Chavali, Venkata R M et al. (2018) The MT-CO1 V83I Polymorphism is a Risk Factor for Primary Open-Angle Glaucoma in African American Men. Invest Ophthalmol Vis Sci 59:1751-1759
Radonjic, Ana; Ding, Xiaomao; Krieger, Avery et al. (2018) Illumination discrimination in the absence of a fixed surface-reflectance layout. J Vis 18:11
Song, Ji Yun; Aravand, Puya; Nikonov, Sergei et al. (2018) Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness. Mol Ther 26:1581-1593
Dedania, Vaidehi S; Zacks, David N; Pan, Wei et al. (2018) TESTOSTERONE SUPPLEMENTATION AND RETINAL VASCULAR DISEASE. Retina 38:2247-2252
Ying, Gui-Shuang; Maguire, Maureen G; Glynn, Robert et al. (2018) Tutorial on Biostatistics: Statistical Analysis for Correlated Binary Eye Data. Ophthalmic Epidemiol 25:1-12
Tuten, William S; Cooper, Robert F; Tiruveedhula, Pavan et al. (2018) Spatial summation in the human fovea: Do normal optical aberrations and fixational eye movements have an effect? J Vis 18:6
Sudharsan, Raghavi; Elliott, Michael H; Dolgova, Natalia et al. (2018) Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay. Adv Exp Med Biol 1074:593-601
Cooper, Robert F; Tuten, William S; Dubra, Alfredo et al. (2018) Erratum: Non-invasive assessment of human cone photoreceptor function: erratum. Biomed Opt Express 9:1842
Lyssenko, Nicholas N; Haider, Naqi; Picataggi, Antonino et al. (2018) Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium. J Lipid Res 59:1927-1939
Jensen, Anne K; Ying, Gui-Shuang; Huang, Jiayan et al. (2018) Longitudinal study of the association between thrombocytopenia and retinopathy of prematurity. J AAPOS 22:119-123

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