Abstract

The Image Analysis Core Module was established in 2010 to provide vision researchers at the University of Pennsylvania with access to multidisciplinary expertise in analysis of image data. The module leverages Penn's world-class research and development programs in biomedical image analysis to provide consultation and customization for image processing and analysis, and data visualization and interpretation. In addition to advanced techniques and tools that cover the range of data analysis and processing tasks relevant to quantitative inference in structural and functional imaging studies of the eye and visual pathways, the module provides synergy with the Imaging and Electrophysiology Core Module, in that analysis strategies can be developed hand-in-hand with acquisition strategies. In the upcoming grant cycle, the IACM will continue its successful track record in the development of, and transfer to VRC investigators of, the next generation of methodological innovations in vision research related image analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001583-45
Application #
9769741
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Massengill, Michael T; Ahmed, Chulbul M; Lewin, Alfred S et al. (2018) Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview. Adv Exp Med Biol 1074:185-191
Lu, Wennan; Gómez, Néstor M; Lim, Jason C et al. (2018) The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol 9:242
Guziewicz, Karina E; Cideciyan, Artur V; Beltran, William A et al. (2018) BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure. Proc Natl Acad Sci U S A 115:E2839-E2848
Chen, Xi; Mangalesh, Shwetha; Dandridge, Alexandria et al. (2018) Spectral-Domain OCT Findings of Retinal Vascular-Avascular Junction in Infants with Retinopathy of Prematurity. Ophthalmol Retina 2:963-971
Dhingra, Anuradha; Bell, Brent A; Peachey, Neal S et al. (2018) Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium. Front Cell Neurosci 12:351
Mattar, Marcelo G; Olkkonen, Maria; Epstein, Russell A et al. (2018) Adaptation decorrelates shape representations. Nat Commun 9:3812
Cideciyan, Artur V; Sudharsan, Raghavi; Dufour, Valérie L et al. (2018) Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector. Proc Natl Acad Sci U S A 115:E8547-E8556
Zhang, Harrison G; Ying, Gui-Shuang (2018) Statistical approaches in published ophthalmic clinical science papers: a comparison to statistical practice two decades ago. Br J Ophthalmol 102:1188-1191
Huang, Jing; Huang, Jiayan; Chen, Yong et al. (2018) Evaluation of Approaches to Analyzing Continuous Correlated Eye Data When Sample Size Is Small. Ophthalmic Epidemiol 25:45-54
Gómez, Néstor Más; Lu, Wennan; Lim, Jason C et al. (2018) Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation. FASEB J 32:782-794

Showing the most recent 10 out of 349 publications