Abstract

Resources and Facilities - Bioinformatics Module Bioinformatics server. We have set up a web and ftp server for researchers to exchange large scale data sets, and another bioinformatics server to store and process microarray data sets. Both systems are based on Red Hat Linux. We are also in charge of maintaining a server to automatically backup all data from tens of workstation of faculties, postdocs, students and technicians in the Wilmer. Bioinformatics workstation. We have 5 Dell Precision 690 Workstations with Xeon 3G Hz CPU, 4G memory, 500 G Disk storage, 19-in flat panel display, and facilities for a rewritable DVD. The workstations run Microsoft Windows 7/Vista/XP and Red Hat Linux. Bioinformatics software and databases. We utilize both public-access and commercial bioinformatics software (including ImagaGene, VectorNTI, GeneSight, almaZen, GeneTraffic, Partek). We also subscribe the update of professional version of the transcription factor database TRANSFAC. In some cases, we utilized publicly available packages such as R-Bioconductor then organized the results based on our collaborators' requests. Sometimes, we wrote our own codes in R, Matlab, Perl, etc. to customize the programs for individual needs of our researchers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001765-43
Application #
9532850
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
43
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205

  Publications

Zhang, Zhi; Jyoti, Amar; Balakrishnan, Bindu et al. (2018) Trajectory of inflammatory and microglial activation markers in the postnatal rabbit brain following intrauterine endotoxin exposure. Neurobiol Dis 111:153-162
Bressler, Eric M; Kim, Jayoung; Shmueli, Ron B et al. (2018) Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple-negative breast cancer cells. J Biomed Mater Res A 106:1753-1764
Liu, Yuanyuan; Fortmann, Seth D; Shen, Jikui et al. (2018) AAV8-antiVEGFfab Ocular Gene Transfer for Neovascular Age-Related Macular Degeneration. Mol Ther 26:542-549
Bhutto, Imran A; Ogura, Shuntaro; Baldeosingh, Rajkumar et al. (2018) An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy. Invest Ophthalmol Vis Sci 59:AMD143-AMD151
Wilson, David R; Sen, Rupashree; Sunshine, Joel C et al. (2018) Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy. Nanomedicine 14:237-246
Fernandes, Kimberly A; Mitchell, Katherine L; Patel, Amit et al. (2018) Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury. Exp Eye Res 171:54-61
Date, Abhijit A; Halpert, Gilad; Babu, Taarika et al. (2018) Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease. Biomaterials 185:97-105
Meyer, Randall A; Mathew, Mohit P; Ben-Akiva, Elana et al. (2018) Anisotropic biodegradable lipid coated particles for spatially dynamic protein presentation. Acta Biomater 72:228-238
Goldberg, Morton F; McLeod, Scott; Tso, Mark et al. (2018) Ocular Histopathology and Immunohistochemical Analysis in the Oldest Known Individual with Autosomal Dominant Vitreoretinochoroidopathy. Ophthalmol Retina 2:360-378
Park, Tea Soon; Zimmerlin, Ludovic; Evans-Moses, Rebecca et al. (2018) Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency. J Vis Exp :

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