We request continuing support for a Vision Research Center in the Department of Ophthalmology. The funds will provide investigators in our Center shared resources that are vital for the continuation of current research programs and efficient development of new programs. Our Center is structured into 42 discrete resource/service modules: Machine Shop; Electronics/Computers; Research Photography-Imaging; and Histology/Microscopy. In addition to enhancing the research environment and productivity by providing common centralized services, our Center stimulates and facilitates collaborative studies and strives to attract to vision research scientists in other health-related disciplines. Our group consists of 9 independent investigators who have NEI grants, 5 associate investigators and fellows. Research is conducted in several scientific disciplines such as biochemistry, pharmacology, physiology, cell biology, and neurology. Areas of active research include glaucoma; cataracts; corneal diseases; aqueous humor dynamics; fluid and electrolyte transport in cornea, lens and ciliary epithelium; role of membrane receptors in regulation of intraocular pressure; electroretinogram and visual evoked potentials; visual control of the oculomotor system; mechanisms of glutamate excitotoxicity in glaucoma and methods of neuroprotection; optical imaging, electrophysiological recordings and computer simulations to study the architecture and dynamics of the visual system; and degenerative diseases of the retina. The support of the CORE Center grant is complemented by a strong commitment of the Department and the Mount Sinai Medical Center to excellence in vision research. NEI funds are requested for 4 of the 7 modules. Our Vision Research Center has facilities with an area of more than 15,000 sq. ft. organized as individual laboratories and common space where modules operate.
| Alvarez, Lawrence J; Zamudio, Aldo C; Candia, Oscar A (2013) Sildenafil stimulates aqueous humor turnover in rabbits. Exp Eye Res 111:67-70 |
| Gerometta, Rosana; Kumar, Sandeep; Shah, Shaily et al. (2013) Reduction of steroid-induced intraocular pressure elevation in sheep by tissue plasminogen activator. Invest Ophthalmol Vis Sci 54:7903-9 |
| Wang, Lingyan; Ly, Christine M; Ko, Chun-Ying et al. (2012) uPA binding to PAI-1 induces corneal myofibroblast differentiation on vitronectin. Invest Ophthalmol Vis Sci 53:4765-75 |
| Gerometta, Rosana; Alvarez, Lawrence J; Candia, Oscar A (2012) Sildenafil accelerates anterior chamber refilling after paracentesis in sheep and rabbits. Invest Ophthalmol Vis Sci 53:565-73 |
| Candia, Oscar A; Mathias, Richard; Gerometta, Rosana (2012) Fluid circulation determined in the isolated bovine lens. Invest Ophthalmol Vis Sci 53:7087-96 |
| Wang, Lingyan; Pedroja, Benjamin S; Meyers, Erin E et al. (2012) Degradation of internalized ?v?5 integrin is controlled by uPAR bound uPA: effect on ?1 integrin activity and ?-SMA stress fiber assembly. PLoS One 7:e33915 |
| Zamudio, Aldo C; Candia, Oscar A (2011) Interaction between mechanical and osmotic forces in the isolated rabbit lens. Exp Eye Res 93:798-803 |
| Gerometta, Rosana; Escobar, D; Candia, Oscar A (2011) An hypothesis on pressure transmission from anterior chamber to optic nerve. Med Hypotheses 77:827-31 |
| Yakushin, Sergei B; Dai, Mingjia; Raphan, Theodore et al. (2011) Spatial orientation of the angular vestibulo-ocular reflex (aVOR) after semicircular canal plugging and canal nerve section. Exp Brain Res 210:583-94 |
| Trexler, E Brady; Casti, Alexander R R; Zhang, Yu (2011) Nonlinearity and noise at the rod-rod bipolar cell synapse. Vis Neurosci 28:61-8 |
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