The broad objective of this application is to facilitate study of visual system function in health and in binding disease with the aim of preventing, mitigating, or curing such disease through the application of the most sophisticated available techniques, including the methods used in molecular biology and molecular genetics. Four support modules will provide these: . Imaging and Computer Module (computer-aided image and data acquisition and analysis); . Molecular Biology Module (molecular localization in tissues using phosphoimaging, DNA sequencing and gene cloning); . Targeted Mutagenesis and Transgenic Animal Module (targeted mutagenesis and development of transgenic animal models); and . In situ Hybridization Module (in Situ hybridization, combined in situ hybridization and immunocytochemistry, and in situ PCR). This application is a competing renewal of a Core Vision Research Grant submitted by the Principal Investigator and 23 other funded investigators. Twelve are NEI-funded, and seven others are funded by non-NIH sources. Of the latter seven, two are submitting NEI R01 renewals, and three are preparing new NEI RO1 applications.
| Hayashi, Genki; Labelle-Dumais, Cassandre; Gould, Douglas B (2018) Use of sodium 4-phenylbutyrate to define therapeutic parameters for reducing intracerebral hemorrhage and myopathy in Col4a1 mutant mice. Dis Model Mech 11: |
| Delwig, Anton; Chaney, Shawnta Y; Bertke, Andrea S et al. (2018) Melanopsin expression in the cornea. Vis Neurosci 35:E004 |
| Choquet, Hélène; Paylakhi, Seyyedhassan; Kneeland, Stephen C et al. (2018) A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Nat Commun 9:2278 |
| Kelley, Kevin W; Ben Haim, Lucile; Schirmer, Lucas et al. (2018) Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength. Neuron 98:306-319.e7 |
| González, Marta Mora; Solano, Marissé Masís; Porco, Travis C et al. (2018) Epidemiology of uveitis in a US population-based study. J Ophthalmic Inflamm Infect 8:6 |
| Paylakhi, Seyyedhassan; Labelle-Dumais, Cassandre; Tolman, Nicholas G et al. (2018) Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error. PLoS Genet 14:e1007244 |
| Lien, Anthony D; Scanziani, Massimo (2018) Cortical direction selectivity emerges at convergence of thalamic synapses. Nature 558:80-86 |
| Resulaj, Arbora; Ruediger, Sarah; Olsen, Shawn R et al. (2018) First spikes in visual cortex enable perceptual discrimination. Elife 7: |
| Biswas, Pooja; Naeem, Muhammad Asif; Ali, Muhammad Hassaan et al. (2018) Whole-Exome Sequencing Identifies Novel Variants that Co-segregates with Autosomal Recessive Retinal Degeneration in a Pakistani Pedigree. Adv Exp Med Biol 1074:219-228 |
| Stryker, Michael P; Löwel, Siegrid (2018) Amblyopia: New molecular/pharmacological and environmental approaches. Vis Neurosci 35:E018 |
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