Abstract

The Core Grant for Vision Research will maintain and expand the common facilities of the Vision Research Center established in the Department of Ophthalmology at Washington University 11 years ago to provide essential services for faculty members whose research interests are in one or another aspect of vision. The Vision Research Center facilitates the interaction between several investigators and makes it possible for them to advance their ongoing research, most of which is supported by individual research grants from NEI. The current application requests continued support for a Service Module, which consists of a machine shop and an electronics shop. In addition there has been a recent change in the chairmanship of the Department of Ophthalmology and Visual Sciences. There has been renewed commitment to research as evidenced by a dramatic increase in the research faculty, as well as renovation and construction of new laboratory space. Therefore, support is also requested for an Immunology Module, a Molecular Biology Module, and a Biostatistics Module to meet the increased needs of the vision research faculty. The research environment at Washington University is very interactive and extends across departmental boundaries. Consequently, a number of the participants in the Core Grant for Vision Research have primary appointments in departments other than that in the Department of Ophthalmology and Visual Sciences.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY002687-12
Application #
3102541
Study Section
Vision Research and Training Committee (VSN)
Project Start
1978-12-01
Project End
1995-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
12
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Ban, Norimitsu; Siegfried, Carla J; Apte, Rajendra S (2018) Monitoring Neurodegeneration in Glaucoma: Therapeutic Implications. Trends Mol Med 24:7-17
Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. J Lipid Res 59:1414-1423
Buckingham, Erin M; Foley, Maria A; Grose, Charles et al. (2018) Identification of Herpes Zoster-Associated Temporal Arteritis Among Cases of Giant Cell Arteritis. Am J Ophthalmol 187:51-60
Stunkel, Leanne; Kung, Nathan H; Wilson, Bradley et al. (2018) Incidence and Causes of Overdiagnosis of Optic Neuritis. JAMA Ophthalmol 136:76-81
Gordon, Mae O; Kass, Michael A (2018) What We Have Learned From the Ocular Hypertension Treatment Study. Am J Ophthalmol 189:xxiv-xxvii
Andley, Usha P; Tycksen, Eric; McGlasson-Naumann, Brittney N et al. (2018) Probing the changes in gene expression due to ?-crystallin mutations in mouse models of hereditary human cataract. PLoS One 13:e0190817
Vinberg, Frans; Peshenko, Igor V; Chen, Jeannie et al. (2018) Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors. J Biol Chem 293:7457-7465
Gordon, Mae O; Higginbotham, Eve J; Heuer, Dale K et al. (2018) Assessment of the Impact of an Endpoint Committee in the Ocular Hypertension Treatment Study. Am J Ophthalmol :
Ruzycki, Philip A; Zhang, Xiaodong; Chen, Shiming (2018) CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites. Epigenetics Chromatin 11:42
Brightman, Diana S; Grant, Rachel L; Ruzycki, Philip A et al. (2018) MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep 8:11902

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