Abstract

Funds are requested to renew core support for 4 core modules. I. Tissue Culture. This laboratory provides modern facilities for the culture of a variety of ocular cells used in different research projects. Five primary and 11 secondary users base important aspects of their research on this laboratory. Core support is requested for a supervisor and basic supplies. II. Histopathology. This important laboratory provides all facilities for tissue processing for light microscopy. It is heavily utilized with 10 primary and 11 secondary users. Core support is requested for a supervisor and basic supplies. III. Ultrastructure (EM). This laboratory provides all equipment and support for scanning and transmission electron microscopy. It is used to full capacity by 5 primary and 17 secondary users. Core support is requested for a supervisor and basic supplies. IV. Vivarium. This modern facility accommodates primates, rodents, rabbits and cats and provides for sterile surgery and special procedures such as necropsy, electroretinography, echography and fundus photography. The vivarium is essential to our entire basic science research effort with 11 primary and 4 secondary users. Core support is requested for a supervisor, a senior vivarium technician and basic supplies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY003040-09
Application #
3102571
Study Section
Vision Research and Training Committee (VSN)
Project Start
1979-09-30
Project End
1989-09-29
Budget Start
1987-09-30
Budget End
1988-09-29
Support Year
9
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Doheny Eye Institute
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90033

  Publications

Kim, Hwa Sun; Huang, Shun-Ping; Lee, Eun-Jin et al. (2018) Identifying Key Networks Linked to Light-Independent Photoreceptor Degeneration in Visual Arrestin 1 Knockout Mice. Adv Exp Med Biol 1074:281-287
Gonzalez Jr, Jose M; Ko, Minhee K; Masedunskas, Andrius et al. (2017) Toward in vivo two-photon analysis of mouse aqueous outflow structure and function. Exp Eye Res 158:161-170
Carelli, Valerio; La Morgia, Chiara; Ross-Cisneros, Fred N et al. (2017) Optic neuropathies: the tip of the neurodegeneration iceberg. Hum Mol Genet 26:R139-R150
Kim, Esther Lee; Tran, Jeffrey; Töteberg-Harms, Marc et al. (2017) Vision Loss and Recovery after Baerveldt Aqueous Tube Shunt Implantation. J Ophthalmol 2017:4140305
La Morgia, Chiara; Ross-Cisneros, Fred N; Koronyo, Yosef et al. (2016) Melanopsin retinal ganglion cell loss in Alzheimer disease. Ann Neurol 79:90-109
Kannan, Ram; Sreekumar, Parameswaran G; Hinton, David R (2016) Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration. Biochim Biophys Acta 1860:258-68
Huang, Alex S; Saraswathy, Sindhu; Dastiridou, Anna et al. (2016) Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes. Transl Vis Sci Technol 5:5
Brant Fernandes, Rodrigo A; Koss, Michael Janusz; Falabella, Paulo et al. (2016) An Innovative Surgical Technique for Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium in Yucatan Mini Pigs: Preliminary Results. Ophthalmic Surg Lasers Imaging Retina 47:342-51
Yu, Wan-Qing; Eom, Yun Sung; Shin, Jung-A et al. (2016) Reshaping the Cone-Mosaic in a Rat Model of Retinitis Pigmentosa: Modulatory Role of ZO-1 Expression in DL-Alpha-Aminoadipic Acid Reshaping. PLoS One 11:e0151668
Giordano, Carla; Carelli, Valerio (2016) Reply: Mitochondrial DNA copy number differentiates the Leber's hereditary optic neuropathy affected individuals from the unaffected mutation carriers. Brain 139:e2

Showing the most recent 10 out of 968 publications