Abstract

Continued support for our Core Grant for Vision Research is requested. The Core consists of five modules: Biometry, Histology/Immunopathology, Tissue Culture/Instrumentation, Ultrastructure/Morphometry and Vivarium. The laboratory modules have been successful and heavily utilized, supporting over 200 publications involving 32 faculty and over 100 collaborations among Doheny faculty during the last five years. The Biometry module was funded 14 months ago and has been very active during the past 9 months, producing 5 protocols and working with 15 clinicians. We propose to continue our Core activities as they are currently constituted, with full-time salary support for our laboratory supervisors; quarter-time salary for the director of Biometry module, full-time salary for a statistician and a half-time salary support for a clinical coordinator. In addition, we have proposed a limited supply and equipment maintenance budget for each module.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY003040-14
Application #
3102575
Study Section
Vision Research and Training Committee (VSN)
Project Start
1979-09-30
Project End
1995-02-28
Budget Start
1993-03-01
Budget End
1994-02-28
Support Year
14
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Doheny Eye Institute
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90033

  Publications

Kim, Hwa Sun; Huang, Shun-Ping; Lee, Eun-Jin et al. (2018) Identifying Key Networks Linked to Light-Independent Photoreceptor Degeneration in Visual Arrestin 1 Knockout Mice. Adv Exp Med Biol 1074:281-287
Gonzalez Jr, Jose M; Ko, Minhee K; Masedunskas, Andrius et al. (2017) Toward in vivo two-photon analysis of mouse aqueous outflow structure and function. Exp Eye Res 158:161-170
Carelli, Valerio; La Morgia, Chiara; Ross-Cisneros, Fred N et al. (2017) Optic neuropathies: the tip of the neurodegeneration iceberg. Hum Mol Genet 26:R139-R150
Kim, Esther Lee; Tran, Jeffrey; Töteberg-Harms, Marc et al. (2017) Vision Loss and Recovery after Baerveldt Aqueous Tube Shunt Implantation. J Ophthalmol 2017:4140305
Ishikawa, Keijiro; Sreekumar, Parameswaran G; Spee, Christine et al. (2016) ?B-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition. Am J Pathol 186:859-73
Ko, MinHee K; Kim, Eun Kyoung; Gonzalez Jr, Jose M et al. (2016) Dose- and time-dependent effects of actomyosin inhibition on live mouse outflow resistance and aqueous drainage tissues. Sci Rep 6:21492
Francis, Brian A; Loewen, Nils; Hong, Bryan et al. (2016) Repeatability of selective laser trabeculoplasty for open-angle glaucoma. BMC Ophthalmol 16:128
Lima, Luiz H; Morales, Yael; Cabral, Thiago (2016) Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM). J Ophthalmol 2016:5356371
Eandi, Chiara M; Charles Messance, Hugo; Augustin, Sébastien et al. (2016) Subretinal mononuclear phagocytes induce cone segment loss via IL-1?. Elife 5:
Boado, Ruben J; Lu, Jeff Zhiqiang; Hui, Eric Ka-Wai et al. (2016) Insulin Receptor Antibody-?-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts. Mol Pharm 13:1385-92

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