Funds are requested by 26 vision scientists to support 4 research modules that facilitate and enhance interaction among the vision scientists in the various disciplines represented at the Schepens Eye Research Institute. The modules will extend endeavors of individual research programs by providing collaborative opportunities for projects in which investigators do not have expertise, funding, or technical capabilities. The modules are: Morphology, Animal Resource, Laboratory Computer Applications and Flow Cytometry. The Morphology Module will provide light and electron microscopy, confocal microscopy and tissue preparation for histochemistry and in situ hybridization, thereby increasing the availability of morphologic techniques to biochemists, pharmacologists, cell and molecular biologists, and immunologists who need correlative morphologic data for their research. The module houses and maintains shared equipment for morphological work and is available to all members of the Core. The Animal Resource Module will provide expertise and assistance in animal surgical techniques and postoperative care, administration of anesthesia, drugs, and medications. In addition, it will also provide for daily animal husbandry that is required to maintain our high standards for animal housing, sanitation, and veterinary care. The Laboratory Computer Applications Module will provide support to individual and collaborative efforts by assisting in interfacing of microcomputers with lab equipment and by selecting or developing software for gathering, processing, and analyzing experimental data by microcomputer systems. The module will also provide assistance to projects involving image processing and analysis from several types of equipment sources. The module interacts actively with the Morphology and Flow Cytometry Modules supporting computer-based technology. The Flow Cytometry Module is a centralized service providing principal investigators and collaborators access to equipment and technical support for flow cytometry and cell sorting. Available to the investigators are the Cytomation MoFlo Ultra-high speed cell sorter, an EPICS SL analyzer, and a CompuCyte Laser Scanning Cytometer. The modules are staffed by personnel with specialized training in the respective fields and equipment. Each module is under the immediate supervision of an established, experienced investigator(s). The module heads constitute the Core Grant Committee, which is responsible to the Director of Research. ? ? ? ?
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| Paschalis, Eleftherios I; Lei, Fengyang; Zhou, Chengxin et al. (2018) Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes. Proc Natl Acad Sci U S A 115:E11359-E11368 |
| Chen, Huihui; Cho, Kin-Sang; Vu, T H Khanh et al. (2018) Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. Nat Commun 9:3209 |
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| Sahu, Srikant K; Mittal, Sharad K; Foulsham, William et al. (2018) Mast Cells Initiate the Recruitment of Neutrophils Following Ocular Surface Injury. Invest Ophthalmol Vis Sci 59:1732-1740 |
| Mittal, Sharad K; Mashaghi, Alireza; Amouzegar, Afsaneh et al. (2018) Mesenchymal Stromal Cells Inhibit Neutrophil Effector Functions in a Murine Model of Ocular Inflammation. Invest Ophthalmol Vis Sci 59:1191-1198 |
| Reeves, Adam; Grayhem, Rebecca; Hwang, Alex D (2018) Rapid Adaptation of Night Vision. Front Psychol 9:8 |
| Jung, Jae-Hyun; Peli, Eli (2018) Field Expansion for Acquired Monocular Vision Using a Multiplexing Prism. Optom Vis Sci 95:814-828 |
| Gupta, Priya R; Pendse, Nachiket; Greenwald, Scott H et al. (2018) Ift172 conditional knock-out mice exhibit rapid retinal degeneration and protein trafficking defects. Hum Mol Genet 27:2012-2024 |
| García-Caballero, Cristina; Lieppman, Burke; Arranz-Romera, Alicia et al. (2018) Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice. Mol Vis 24:733-745 |
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