(Administrative Core) Continuing funds are requested by 17 vision scientists (holding 13 eligible NEI R01 grants) and their personnel to support an administrative core and three resource/service cores in the newly merged Department of Ophthalmology, Visual and Anatomical Sciences (former Ophthalmology and Anatomy/Cell Biology Departments). The Administrative core will support the overall management of the Center Core. Its organizational structure is designed to be sufficiently robust and able to integrate the activities of the three research (Resource) cores and to determine funds flow and their utilization. The overall administration of the Core grant will remain the responsibility of the PD/PI, Dr. Hazlett, in concert with the research core directors. The Administrative core will be used to provide integration, coordination and evaluation of the activities of the three resource/service cores. The Administrative core will be the vehicle by which we establish priorities, allocate resources and provide mechanisms to schedule use of a resource/service core among participating investigators. An External Advisory committee is also in place to provide oversight and review, if the need occurs. The Administrative core will be staffed by a business manager (for whom partial support is requested), secretarial and other administrative support to carry out specific activities related to the Core Vision Grant, which include providing fiscal management and integrating core activities within the institution and academic administrations. For this activity, two positions, one clerical and the other accounting will continue to be funded by the School of Medicine General Fund allocation to the Ophthalmology, Visual, and Anatomical Sciences Department for which Dr. Hazlett has oversight and responsibility to manage and balance the Research budget as vice chair of the department.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY004068-36
Application #
9771799
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
36
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Guest, John M; Singh, Pawan Kumar; Revankar, Sanjay G et al. (2018) Isavuconazole for Treatment of Experimental Fungal Endophthalmitis Caused by Aspergillus fumigatus. Antimicrob Agents Chemother 62:
Berkowitz, Bruce A; Podolsky, Robert H; Qian, Haohua et al. (2018) Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo. Invest Ophthalmol Vis Sci 59:5957-5964
Cui, Xinhan; Gao, Nan; Me, Rao et al. (2018) TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway. Invest Ophthalmol Vis Sci 59:4228-4237
Lu, Qi; Ganjawala, Tushar H; Hattar, Samer et al. (2018) A Robust Optomotor Assay for Assessing the Efficacy of Optogenetic Tools for Vision Restoration. Invest Ophthalmol Vis Sci 59:1288-1294
Ekanayaka, Sandamali A; McClellan, Sharon A; Peng, Xudong et al. (2018) HMGB1 Antagonist, Box A, Reduces TLR4, RAGE, and Inflammatory Cytokines in the Cornea of P. aeruginosa-Infected Mice. J Ocul Pharmacol Ther :
Jiang, Youde; Liu, Li; Steinle, Jena J (2018) Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature. Mol Vis 24:727-732
Berkowitz, Bruce A (2018) Oxidative stress measured in vivo without an exogenous contrast agent using QUEST MRI. J Magn Reson 291:94-100
Shi, Haoshen; Ebrahim, Abdul S; Berger, Elizabeth A (2018) A Contrast in Pathogenic Responses between C57BL/6J and BALB/cJ Mice Using a Model of Retinal Injury. Am J Pathol 188:2717-2728
Curtiss, Elizabeth; Liu, Li; Steinle, Jena J (2018) miR15a regulates NLRP3 inflammasome proteins in the retinal vasculature. Exp Eye Res 176:98-102
Gao, Nan; Me, Rao; Dai, Chenyang et al. (2018) Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6 Mouse Corneas. J Immunol 201:688-699

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