Abstract

This is a new application for support of Core vision research facilities, at the Institute of Biological Sciences, Oakland University. This organization is described as an independent academic unit (equivalent to a school or college), with a mission to conduct research in vision sciences and to provide an environment for research training. Research of the group's members has some common themes (cataract etiology, membrane phenomena, transport processes and the role of glutathione metabolism in oxidative damage to cells, for example), in such areas as glaucoma, cornea and retinal and choroidal diseases, in addition to cataract. In an effort to enhance collaborative research in these areas, support is asked for five modules. Module 1: Electron microscopy and Histology Module 2: Tissue culture Module 3: Instrumentation Module 4: Animal facility Module 5: Administrative core

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
1P30EY005230-01
Application #
3102611
Study Section
Vision Research and Training Committee (VSN)
Project Start
1985-03-01
Project End
1990-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Oakland University
Department
Type
Organized Research Units
DUNS #
City
Rochester
State
MI
Country
United States
Zip Code
48309

  Publications

Kasahara, Emiko; Lin, Li-Ren; Ho, Ye-Shih et al. (2005) SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci 46:3426-34
Reddan, John R; Giblin, Frank J; Sevilla, Michael et al. (2003) Propyl gallate is a superoxide dismutase mimic and protects cultured lens epithelial cells from H2O2 insult. Exp Eye Res 76:49-59
Winkler, Barry S; Pourcho, Roberta G; Starnes, Catherine et al. (2003) Metabolic mapping in mammalian retina: a biochemical and 3H-2-deoxyglucose autoradiographic study. Exp Eye Res 77:327-37
Winkler, B S; Kapousta-Bruneau, N; Arnold, M J et al. (1999) Effects of inhibiting glutamine synthetase and blocking glutamate uptake on b-wave generation in the isolated rat retina. Vis Neurosci 16:345-53
Bucolo, C; Lin, L R; Dang, L et al. (1994) The effect of ganglioside on oxidation-induced permeability changes in lens and in epithelial cells of lens and retina. Exp Eye Res 58:697-704
Riley, M V; Winkler, B S; Peters, M I et al. (1994) Relationship between fluid transport and in situ inhibition of Na(+)-K+ adenosine triphosphatase in corneal endothelium. Invest Ophthalmol Vis Sci 35:560-7
Yokoyama, T; Sasaki, H; Giblin, F J et al. (1994) A physiological level of ascorbate inhibits galactose cataract in guinea pigs by decreasing polyol accumulation in the lens epithelium: a dehydroascorbate-linked mechanism. Exp Eye Res 58:207-18
Hightower, K R (1994) A review of the evidence that ultraviolet irradiation is a risk factor in cataractogenesis. Doc Ophthalmol 88:205-20
Hightower, K; McCready, J (1994) Selenite-induced damage to lens membranes. Exp Eye Res 58:225-9
Shastry, B S; Reddy, V N (1994) Studies on congenital hereditary cataract and microphthalmia of the miniature schnauzer dog. Biochem Biophys Res Commun 203:1663-7

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