Abstract

The objective of the core grant at the Eye Research Institute of Oakland University is to enhance ophthalmic research and promote cooperative vision research not only among the faculty of the Institute but with other members of the vision research community within the University and the clinical faculty from the Department of Ophthalmology of the William Beaumont Hospital. The centralized core facilities of the Eye Research Institute are an important component of our resources, which have not only extended the research capabilities of the major users of the shared facilities, but have served as an important catalyst for interdisciplinary collaboration among basic science faculty and clinical ophthalmologists. The Core facilities provide a rich environment for the training of residents and fellows in ophthalmology. Although the establishment of a Core module for Biostatistics for clinical traits remains a future goal, at this time it is proposed to continue the existing Core facilities of: 1) Tissue Culture, 2) Electron Microscopy/Histology, 3) Animal Holding/Animal Surgery, 4) Administration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY005230-10
Application #
2159345
Study Section
Vision Research and Training Committee (VSN)
Project Start
1985-03-01
Project End
1995-03-31
Budget Start
1994-03-01
Budget End
1995-03-31
Support Year
10
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Oakland University
Department
Type
Organized Research Units
DUNS #
City
Rochester
State
MI
Country
United States
Zip Code
48309

  Publications

Kasahara, Emiko; Lin, Li-Ren; Ho, Ye-Shih et al. (2005) SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci 46:3426-34
Reddan, John R; Giblin, Frank J; Sevilla, Michael et al. (2003) Propyl gallate is a superoxide dismutase mimic and protects cultured lens epithelial cells from H2O2 insult. Exp Eye Res 76:49-59
Winkler, Barry S; Pourcho, Roberta G; Starnes, Catherine et al. (2003) Metabolic mapping in mammalian retina: a biochemical and 3H-2-deoxyglucose autoradiographic study. Exp Eye Res 77:327-37
Winkler, B S; Kapousta-Bruneau, N; Arnold, M J et al. (1999) Effects of inhibiting glutamine synthetase and blocking glutamate uptake on b-wave generation in the isolated rat retina. Vis Neurosci 16:345-53
Bucolo, C; Lin, L R; Dang, L et al. (1994) The effect of ganglioside on oxidation-induced permeability changes in lens and in epithelial cells of lens and retina. Exp Eye Res 58:697-704
Riley, M V; Winkler, B S; Peters, M I et al. (1994) Relationship between fluid transport and in situ inhibition of Na(+)-K+ adenosine triphosphatase in corneal endothelium. Invest Ophthalmol Vis Sci 35:560-7
Yokoyama, T; Sasaki, H; Giblin, F J et al. (1994) A physiological level of ascorbate inhibits galactose cataract in guinea pigs by decreasing polyol accumulation in the lens epithelium: a dehydroascorbate-linked mechanism. Exp Eye Res 58:207-18
Hightower, K R (1994) A review of the evidence that ultraviolet irradiation is a risk factor in cataractogenesis. Doc Ophthalmol 88:205-20
Hightower, K; McCready, J (1994) Selenite-induced damage to lens membranes. Exp Eye Res 58:225-9
Shastry, B S; Reddy, V N (1994) Studies on congenital hereditary cataract and microphthalmia of the miniature schnauzer dog. Biochem Biophys Res Commun 203:1663-7

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