Abstract

The overall objective of the Core Center Grant at the Eye Research Institute at Oakland University is to further enhance the research capabilities of the Institute's faculty and to promote cooperative research among the vision research community within the university and the clinical faculty of the affiliated Department of Ophthalmology at the William Beaumont Hospital. The centralized core facilities of the Eye Research Institute are an important component of our resources to sustain and extend the research capabilities of major users of the shared facilities. They have served to attract new faculty to the vision research group, and are an important catalyst for interdisciplinary collaboration among basic science faculty and clinical ophthalmologists. The Core facilities also provide an excellent environment for research training of Residents and Fellows in Ophthalmology. The proposed renewal application is for the continuation of the existing Core modules of: l) Tissue Culture; 2) Electron Microscopy/Histology, and 3) Animal Holding/Animal Surgery

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY005230-13
Application #
2391670
Study Section
Special Emphasis Panel (SRC (02))
Project Start
1985-03-01
Project End
2000-03-31
Budget Start
1997-04-01
Budget End
1998-03-31
Support Year
13
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Oakland University
Department
Type
Organized Research Units
DUNS #
City
Rochester
State
MI
Country
United States
Zip Code
48309

  Publications

Kasahara, Emiko; Lin, Li-Ren; Ho, Ye-Shih et al. (2005) SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci 46:3426-34
Reddan, John R; Giblin, Frank J; Sevilla, Michael et al. (2003) Propyl gallate is a superoxide dismutase mimic and protects cultured lens epithelial cells from H2O2 insult. Exp Eye Res 76:49-59
Winkler, Barry S; Pourcho, Roberta G; Starnes, Catherine et al. (2003) Metabolic mapping in mammalian retina: a biochemical and 3H-2-deoxyglucose autoradiographic study. Exp Eye Res 77:327-37
Winkler, B S; Kapousta-Bruneau, N; Arnold, M J et al. (1999) Effects of inhibiting glutamine synthetase and blocking glutamate uptake on b-wave generation in the isolated rat retina. Vis Neurosci 16:345-53
Bucolo, C; Lin, L R; Dang, L et al. (1994) The effect of ganglioside on oxidation-induced permeability changes in lens and in epithelial cells of lens and retina. Exp Eye Res 58:697-704
Riley, M V; Winkler, B S; Peters, M I et al. (1994) Relationship between fluid transport and in situ inhibition of Na(+)-K+ adenosine triphosphatase in corneal endothelium. Invest Ophthalmol Vis Sci 35:560-7
Yokoyama, T; Sasaki, H; Giblin, F J et al. (1994) A physiological level of ascorbate inhibits galactose cataract in guinea pigs by decreasing polyol accumulation in the lens epithelium: a dehydroascorbate-linked mechanism. Exp Eye Res 58:207-18
Hightower, K R (1994) A review of the evidence that ultraviolet irradiation is a risk factor in cataractogenesis. Doc Ophthalmol 88:205-20
Hightower, K; McCready, J (1994) Selenite-induced damage to lens membranes. Exp Eye Res 58:225-9
Shastry, B S; Reddy, V N (1994) Studies on congenital hereditary cataract and microphthalmia of the miniature schnauzer dog. Biochem Biophys Res Commun 203:1663-7

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