Abstract

The Structural Biology and Imaging (SBI) Core enhances vision research of AVRC members by assisting them in determining the relationship between normal and abnormal tissue structure in eye diseases, disease models and after experimental treatments. This SBI Core provides facilities and services for AVRC members to determine structural changes and how they relate to function through histology, electron microscopy, confocal scanning laser microscopy and experimental animal surgery imaging. The SBI Core also supports obtaining structural data and interpretation of this data for new initiatives of AVRC members with an emphasis on retinal function, retinal degeneration/injury, RPE morphometry, ocular oncology, and gene/drug delivery. The SBI Core enables localization of proteins involved with control of retinal function in health and disease; imaging of tissue changes in retinal and optic nerve degenerations; correlation of RPE morphometric changes with genotype and function; development of imaging techniques for primary and metastatic ocular tumors, including tissue correlations with MRI contrast agents and tele-imaging; and studying ocular tissue changes relative to gene and drug delivery to the posterior ocular compartment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY006360-31
Application #
9153091
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
31
Fiscal Year
2016
Total Cost
$120,288
Indirect Cost
$61,285

  Institution

Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Dattilo, Michael; Newman, Nancy J; Biousse, Valérie (2018) Acute retinal arterial ischemia. Ann Eye Sci 3:
Kang, Seong Su; Ahn, Eun Hee; Zhang, Zhentao et al. (2018) ?-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease. EMBO J 37:
Lu, Ye; Zhou, Diana; King, Rebecca et al. (2018) The genetic dissection of Myo7a gene expression in the retinas of BXD mice. Mol Vis 24:115-126
Peragallo, Jason H; Keller, Stephanie; van der Knaap, Marjo S et al. (2018) Retinopathy and optic atrophy: Expanding the phenotypic spectrum of pathogenic variants in the AARS2 gene. Ophthalmic Genet 39:99-102
Struebing, Felix L; King, Rebecca; Li, Ying et al. (2018) Genomic loci modulating retinal ganglion cell death following elevated IOP in the mouse. Exp Eye Res 169:61-67
Liao, Albert; Mittal, Pardeep; Lawson, David H et al. (2018) Radiologic and Histopathologic Correlation of Different Growth Patterns of Metastatic Uveal Melanoma to the Liver. Ophthalmology 125:597-605
Liu, Yi-Hsia; Corbett, Clare; Klaska, Izabela P et al. (2018) Partial retinal photoreceptor loss in a transgenic mouse model associated with reduced levels of interphotoreceptor retinol binding protein (IRBP, RBP3). Exp Eye Res 172:54-65
Smith, Jesse M; Ward, Laura T; Townsend, Justin H et al. (2018) Rhegmatogenous Retinal Detachment in Children: Clinical Factors Predictive of Successful Surgical Repair. Ophthalmology :
Sankaran, Mathangi; Keeley, Patrick W; He, Li et al. (2018) Dopaminergic amacrine cell number, plexus density, and dopamine content in the mouse retina: Strain differences and effects of Bax gene disruption. Exp Eye Res 177:208-212
Allen, Rachael S; Motz, Cara T; Feola, Andrew et al. (2018) Long-Term Functional and Structural Consequences of Primary Blast Overpressure to the Eye. J Neurotrauma 35:2104-2116

Showing the most recent 10 out of 896 publications