The Core Grant for Vision Research at the University of Michigan. supports four modules: 1) A Machine Shop Module for designing and constructing mechanical instrumentation, staffed by an instrument maker; 2) an Electronics Shop Module for the designing and constructing of electronics equipment, staffed by an electrical engineer and an electronics technician; 3) a Morphology and Imaging Module for the processing of ocular tissue for light and electron microscopy, immunohistochemistry and in situ hybridization, as well as the production of black and white photographs and digital images, staffed by a technician; and, 4) a Vivarium Module for the housing and care of laboratory animals used in vision research, staffed by a veterinary technician.
The specific aims of the Core Grant for Vision Research at the University of Michigan are to enhance the research environment for vision scientists, facilitate collaborative studies of the visual system and its diseases, and expand vision research on this campus to bring the skill and perspective of non-vision scientists to bear upon research issues of the visual system. The 19 participating investigators of the Core currently hold 15 NEI grants, with 2 additional grant applications pending. The research interests of these investigators are diverse and include electrophysiology, neurobiology, biochemistry, molecular biology, molecular genetics, immunology, and clinical ophthalmology. The Core Grant will be housed within the W.K. Kellogg Eye Center, a 120,000 sq. ft. building containing space dedicated to each of the modules, plus state-of-the-art facilities for basic and clinical research.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY007003-12
Application #
2701366
Study Section
Special Emphasis Panel (ZEY1-VSN (02))
Project Start
1987-05-01
Project End
2002-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Ramos, Carla J; Lin, Chengmao; Liu, Xuwen et al. (2018) The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. J Biol Chem 293:717-730
Tian, Chao; Zhang, Wei; Nguyen, Van Phuc et al. (2018) Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes. J Vis Exp :
Fernando, Roshini; Grisolia, Ana Beatriz Diniz; Lu, Yan et al. (2018) Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' Disease. J Immunol 200:3942-3949
Zhang, Haonan; Xie, Xinyi; Li, Jia et al. (2018) Removal of choroidal vasculature using concurrently applied ultrasound bursts and nanosecond laser pulses. Sci Rep 8:12848
Kiang, Lee; Ross, Bing X; Yao, Jingyu et al. (2018) Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment. Invest Ophthalmol Vis Sci 59:3767-3778
Saera-Vila, Alfonso; Louie, Ke'ale W; Sha, Cuilee et al. (2018) Extraocular muscle regeneration in zebrafish requires late signals from Insulin-like growth factors. PLoS One 13:e0192214
Lu, Yan; Atkins, Stephen J; Fernando, Roshini et al. (2018) CD34- Orbital Fibroblasts From Patients With Thyroid-Associated Ophthalmopathy Modulate TNF-? Expression in CD34+ Fibroblasts and Fibrocytes. Invest Ophthalmol Vis Sci 59:2615-2622
Bian, Zong-Mei; Field, Matthew G; Elner, Susan G et al. (2018) Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1? and MCP-1 in cultured human retinal pigment epithelial cells. Exp Eye Res 170:29-39
Cao, Xu; Pattnaik, Bikash R; Hughes, Bret A (2018) Mouse retinal pigment epithelial cells exhibit a thiocyanate-selective conductance. Am J Physiol Cell Physiol 315:C457-C473
Chawla, Bahaar; Swain, William; Williams, Antionette L et al. (2018) Retinoic Acid Maintains Function of Neural Crest-Derived Ocular and Craniofacial Structures in Adult Zebrafish. Invest Ophthalmol Vis Sci 59:1924-1935

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