Abstract

- BIO-IMAGING AND CONFOCAL MICROSCOPY The Bio-Imaging & Confocal Microscopy Core at OHSU will provide instrumentation and support for fluorescence and confocal microscopy as well as spectral domain optical coherence tomography (SDOCT) to enhance and facilitate vision research at OHSU. The major instrumentation and expertise are already in place at the Casey Eye Institute (CEI). Past P30 support of confocal and fluorescence imaging systems at the CEI has been extremely successful, with data from the supported instruments featuring in 50 publications during the previous 5-year funding period. Changes in the next funding period include the addition of small animal SDOCT instrumentation to the Core. The Bioptigen SDOCT device makes possible repeated, noninvasive, in vivo imaging of the retina and eye and will substantially enhance ongoing and planned research projects at CEI aimed at improving the treatment of visual diseases. Dr. Catherine Morgans, an expert in confocal and fluorescence microscopy, will continue to serve as Director of the Bio-Imaging Core, and Dr. Mark Pennessi, expert at rodent SDOCT, along with Dr. David Huang, co-inventor of OCT technology, will provide guidance and training to new SDOCT users. Training opportunities on all instruments will be available to principal investigators, postdoctoral fellows, and graduate students.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY010572-24
Application #
9552819
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
24
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Camino, Acner; Zhang, Miao; Liu, Liang et al. (2018) Enhanced Quantification of Retinal Perfusion by Improved Discrimination of Blood Flow From Bulk Motion Signal in OCTA. Transl Vis Sci Technol 7:20
Niffenegger, John H; Soltero, Arysol; Niffenegger, James S et al. (2018) Prevalence of Hepatocyte Growth Factor and Autoantibodies to ?-HGF as a New Etiology for Bilateral Diffuse Uveal Melanocytic Proliferation Masquerading as Neovascular Age-Related Macular Degeneration. J Clin Exp Ophthalmol 9:
Yang, Sungjae; Kopplin, Laura J; Rosenbaum, James T (2018) Retinal vasculitis associated with CREST syndrome. Am J Ophthalmol Case Rep 10:185-188
Hribar, Michelle R; Huang, Abigail E; Goldstein, Isaac H et al. (2018) Data-Driven Scheduling for Improving Patient Efficiency in Ophthalmology Clinics. Ophthalmology :
Loh, Allison R; Edmunds, Beth; Peter Campbell, J et al. (2018) Ophthalmic imaging in children: current practice patterns and perceived barriers. J AAPOS 22:223-225.e3
Hagag, Ahmed M; Pechauer, Alex D; Liu, Liang et al. (2018) OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia. Ophthalmol Retina 2:329-336
Lu, Yansha; Simonett, Joseph M; Wang, Jie et al. (2018) Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci 59:2212-2221
Kim, Sang Jin; Port, Alexander D; Swan, Ryan et al. (2018) Retinopathy of prematurity: a review of risk factors and their clinical significance. Surv Ophthalmol 63:618-637
Adamus, Grazyna (2018) Are Anti-Retinal Autoantibodies a Cause or a Consequence of Retinal Degeneration in Autoimmune Retinopathies? Front Immunol 9:765
Watson, Spencer S; Dane, Mark; Chin, Koei et al. (2018) Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes. Cell Syst 6:329-342.e6

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