Abstract

- BIO-IMAGING AND CONFOCAL MICROSCOPY The Bio-Imaging & Confocal Microscopy Core at OHSU will provide instrumentation and support for fluorescence and confocal microscopy as well as spectral domain optical coherence tomography (SDOCT) to enhance and facilitate vision research at OHSU. The major instrumentation and expertise are already in place at the Casey Eye Institute (CEI). Past P30 support of confocal and fluorescence imaging systems at the CEI has been extremely successful, with data from the supported instruments featuring in 50 publications during the previous 5-year funding period. Changes in the next funding period include the addition of small animal SDOCT instrumentation to the Core. The Bioptigen SDOCT device makes possible repeated, noninvasive, in vivo imaging of the retina and eye and will substantially enhance ongoing and planned research projects at CEI aimed at improving the treatment of visual diseases. Dr. Catherine Morgans, an expert in confocal and fluorescence microscopy, will continue to serve as Director of the Bio-Imaging Core, and Dr. Mark Pennessi, expert at rodent SDOCT, along with Dr. David Huang, co-inventor of OCT technology, will provide guidance and training to new SDOCT users. Training opportunities on all instruments will be available to principal investigators, postdoctoral fellows, and graduate students.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY010572-25
Application #
9762948
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
25
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Pennesi, Mark E; Birch, David G; Jayasundera, K Thiran et al. (2018) Prospective Evaluation of Patients With X-Linked Retinoschisis During 18 Months. Invest Ophthalmol Vis Sci 59:5941-5956
Hegarty, Deborah M; David, Larry L; Aicher, Sue A (2018) Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception. Invest Ophthalmol Vis Sci 59:5217-5224
Ting, Daniel Shu Wei; Pasquale, Louis R; Peng, Lily et al. (2018) Artificial intelligence and deep learning in ophthalmology. Br J Ophthalmol :
Patel, Rachel; Wang, Jie; Campbell, J Peter et al. (2018) Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography. Invest Ophthalmol Vis Sci 59:4285-4291
Lu, Jonathan E; Francis, Jasmine H; Dunkel, Ira J et al. (2018) Metastases and death rates after primary enucleation of unilateral retinoblastoma in the USA 2007-2017. Br J Ophthalmol :
Al-Qahtani, Abdullah A; Ba-Ali, Shakoor; Alabduljalil, Talal et al. (2018) SCLERAL PITS IN CHOROIDEREMIA: Implications for Retinal Gene Therapy. Retina 38:1725-1730
Spain, Rebecca I; Liu, Liang; Zhang, Xinbo et al. (2018) Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis. Br J Ophthalmol 102:520-524
Hulett, Tyler W; Jensen, Shawn M; Wilmarth, Phillip A et al. (2018) Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination. J Immunother Cancer 6:27
Boese, Erin A; Huang, David; Tehrani, Shandiz (2018) Unilateral Double Optic Nerve Head Pits. Ophthalmology 125:458
Vranka, Janice A; Staverosky, Julia A; Reddy, Ashok P et al. (2018) Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures. Invest Ophthalmol Vis Sci 59:246-259

Showing the most recent 10 out of 429 publications