Abstract

- BIO-IMAGING AND CONFOCAL MICROSCOPY The Bio-Imaging & Confocal Microscopy Core at OHSU will provide instrumentation and support for fluorescence and confocal microscopy as well as spectral domain optical coherence tomography (SDOCT) to enhance and facilitate vision research at OHSU. The major instrumentation and expertise are already in place at the Casey Eye Institute (CEI). Past P30 support of confocal and fluorescence imaging systems at the CEI has been extremely successful, with data from the supported instruments featuring in 50 publications during the previous 5-year funding period. Changes in the next funding period include the addition of small animal SDOCT instrumentation to the Core. The Bioptigen SDOCT device makes possible repeated, noninvasive, in vivo imaging of the retina and eye and will substantially enhance ongoing and planned research projects at CEI aimed at improving the treatment of visual diseases. Dr. Catherine Morgans, an expert in confocal and fluorescence microscopy, will continue to serve as Director of the Bio-Imaging Core, and Dr. Mark Pennessi, expert at rodent SDOCT, along with Dr. David Huang, co-inventor of OCT technology, will provide guidance and training to new SDOCT users. Training opportunities on all instruments will be available to principal investigators, postdoctoral fellows, and graduate students.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY010572-25
Application #
9762948
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
25
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Hagag, Ahmed M; Pechauer, Alex D; Liu, Liang et al. (2018) OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia. Ophthalmol Retina 2:329-336
Loh, Allison R; Edmunds, Beth; Peter Campbell, J et al. (2018) Ophthalmic imaging in children: current practice patterns and perceived barriers. J AAPOS 22:223-225.e3
Kim, Sang Jin; Port, Alexander D; Swan, Ryan et al. (2018) Retinopathy of prematurity: a review of risk factors and their clinical significance. Surv Ophthalmol 63:618-637
Lu, Yansha; Simonett, Joseph M; Wang, Jie et al. (2018) Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci 59:2212-2221
Watson, Spencer S; Dane, Mark; Chin, Koei et al. (2018) Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes. Cell Syst 6:329-342.e6
Adamus, Grazyna (2018) Are Anti-Retinal Autoantibodies a Cause or a Consequence of Retinal Degeneration in Autoimmune Retinopathies? Front Immunol 9:765
Shahidi, Mahnaz; Felder, Anthony E; Tan, Ou et al. (2018) Retinal Oxygen Delivery and Metabolism in Healthy and Sickle Cell Retinopathy Subjects. Invest Ophthalmol Vis Sci 59:1905-1909
Windsor, Matthew A; Sun, Sissi J J; Frick, Kevin D et al. (2018) Estimating Public and Patient Savings From Basic Research-A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy. Am J Ophthalmol 185:115-122
McGill, Trevor J; Stoddard, Jonathan; Renner, Lauren M et al. (2018) Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates. Invest Ophthalmol Vis Sci 59:1374-1383
Hirji, Nashila; Bradley, Patrick D; Li, Shuning et al. (2018) Jalili Syndrome: Cross-sectional and Longitudinal Features of Seven Patients With Cone-Rod Dystrophy and Amelogenesis Imperfecta. Am J Ophthalmol 188:123-130

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