The overall goal of our Center Core is to provide expertise, facilities, and equipment to foster and expand vision research at the University of Wisconsin-Madison. This will be accomplished by four Cores. The Vector and Gene Delivery/Quantitative Molecular Biology Core will facilitate the use of gene delivery methods, qPCR and other molecular methods by core users. The Pathology and Imaging Core will facilitate the use of confocal microscopy, fluorescent and light microscopy, histopathology, specialized tissue staining methods, and image analysis by core users. The Animal Models and Organ Culture Core will facilitate the use of non-human primate, rodent and other animal models of ocular disease, the use of OCT, ERG, VEP to assess visual function, and the use of other visual structure and function outcome measures. The Biostatistics and Epidemiology Resource Core will facilitate proper study designs, the use of power calculations, proper use of statistical measures of significance, and proper data analysis methods for Core users.

Public Health Relevance

The overall goal of our Center Core is to provide expertise, facilities, and equipment to foster and expand vision research at the University of Wisconsin-Madison. This will be accomplished by four Cores. The Vector and Gene Delivery/Quantitative Molecular Biology Core will facilitate the use of gene delivery and molecular biology methods by core users. The Pathology and Imaging Core will facilitate the use of microscopy, histopathology, specialized tissue staining methods, and image analysis by core users. The Animal Models and Organ Culture Core will facilitate the use of non-human primate, rodent and other animal models of ocular disease to assess visual function, and the use of other visual structure and function outcome measures. The Biostatistics and Epidemiology Resource Core will facilitate proper study design and proper data analysis methods for Core users.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY016665-11
Application #
9152458
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
2005-09-01
Project End
2021-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
11
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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Ghanian, Zahra; Mehrvar, Shima; Jamali, Nasim et al. (2018) Time-lapse microscopy of oxidative stress demonstrates metabolic sensitivity of retinal pericytes under high glucose condition. J Biophotonics 11:e201700289
Rouhimoghadam, Milad; Safarian, Shahrokh; Carroll, Jason S et al. (2018) Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing. Front Physiol 9:907

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