CORE 3: ANIMAL MODELS AND ORGAN CULTURE ABSTRACT The goal of the Animal Models Core is to facilitate the use of animals and eye organ culture to study visual function and visual diseases by qualifying NEI funded researchers. We also assist non-qualifying investigators in generating preliminary data for funding. This is accomplished by providing expertise in animal models for glaucoma, retinal degeneration, ocular vascular disease, eye organ culture, and infectious diseases and includes animal handling and anesthesia. We also provide expertise and equipment necessary for the evaluation of visual function and disease including, ERG, multifocal ERG, OCT, retinal imaging, IOP and outflow facility determination. Because we are one of the only, if not the only, Vision Research Core with an associated Regional Primate Center, we are in a unique position to provide access to vision research involving non-human primates. As a result, this core has also facilitated vision research by investigators at other institutions and their papers cite this core.
| Zaitoun, Ismail S; Cikla, Ulas; Zafer, Dila et al. (2018) Attenuation of Retinal Vascular Development in Neonatal Mice Subjected to Hypoxic-Ischemic Encephalopathy. Sci Rep 8:9166 |
| Jamali, Nasim; Sorenson, Christine M; Sheibani, Nader (2018) Vitamin D and regulation of vascular cell function. Am J Physiol Heart Circ Physiol 314:H753-H765 |
| Keller, Kate E; Bhattacharya, Sanjoy K; Borrás, Theresa et al. (2018) Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res 171:164-173 |
| Gimse, Kirstan; Gorzek, Ryan C; Olin, Andrew et al. (2018) Hippocampal Homer1b/c is necessary for contextual fear conditioning and group I metabotropic glutamate receptor mediated long-term depression. Neurobiol Learn Mem 156:17-23 |
| Kaufman, Paul L; Mohr, Mary E; Riccomini, Scott P et al. (2018) Glaucoma Drugs in the Pipeline. Asia Pac J Ophthalmol (Phila) 7:345-351 |
| Lewis, Sarah Aileen; Takimoto, Tetsuya; Mehrvar, Shima et al. (2018) The effect of Tmem135 overexpression on the mouse heart. PLoS One 13:e0201986 |
| Faralli, Jennifer A; Dimeo, Kaylee D; Trane, Ralph M et al. (2018) Absence of a secondary glucocorticoid response in C57BL/6J mice treated with topical dexamethasone. PLoS One 13:e0192665 |
| Aktas, Zeynep; Rao, Hongyu; Slauson, Sarah R et al. (2018) Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork. Invest Ophthalmol Vis Sci 59:298-310 |
| Adelman, Sara; Shinsako, Daniel; Kiland, Julie A et al. (2018) The post-natal development of intraocular pressure in normal domestic cats (Felis catus) and in feline congenital glaucoma. Exp Eye Res 166:70-73 |
| Farnoodian, Mitra; Sorenson, Christine M; Sheibani, Nader (2018) Negative Regulators of Angiogenesis, Ocular Vascular Homeostasis, and Pathogenesis and Treatment of Exudative AMD. J Ophthalmic Vis Res 13:470-486 |
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