RESEARCH PLAN: COMPUTATIONAL OPHTHALMOLOGY MODULE OVERVIEW At UCSD, structural imaging instruments such as the spectral domain optical coherence tomography (SD-OCT) and functional instruments are used extensively in animal (Drs. Weinreb, Freeman, Yu, La Spada, Zhang, Freeman) and human studies of glaucoma (Drs. Weinreb, Ju, Lindsay, Zangwill, Medeiros, Balasubramanian) and retinal disease (Drs. Freeman, Yu, Bartsch, Zhang, Cheng). The recent development and commercialization of imaging instruments such as SD-OCT has brought a significant improvement in our ability to visualize and measure the retina in-vivo in both animals and humans. These instruments have potential to dramatically improve our ability to understand the histopathology of major eyes diseases including glaucoma, age-related macular degeneration and diabetic retinopathy. These instruments represent a generational leap forward in technological development and several orders of magnitude more data than previous instruments. The challenge facing both ophthalmic clinicians and researchers is how best to utilize the vast quantity of data to 1) enhance our understanding of the histopathology of eye diseases, and 2) identify structural biomarkers of disease and its progression toward the ultimate goal of improving patient management. The computational ophthalmology module will provide essential centralized resources to support the computationally intensive analysis of structural imaging and functional tests used in animal and human vision research studies. This module will provide dedicated computational resources with a capacity to meet high computational demands and software toolkits that leverage these computational resources so that researchers can analyze the complex and data intensive retinal datasets (imaging and functional testing) outside of the proprietary software available with each ophthalmic test.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY022589-03
Application #
8689051
Study Section
Special Emphasis Panel (ZEY1-VSN)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
3
Fiscal Year
2014
Total Cost
$188,364
Indirect Cost
$66,839
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Muftuoglu, Ilkay Kilic; Alam, Mostafa; You, Qi Sheng et al. (2018) LONG-TERM REMISSION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION WITH AS-NEEDED ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY. Retina 38:516-522
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Shim, Myoung Sup; Kim, Keun-Young; Noh, Mark et al. (2018) Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line. Biochem Biophys Res Commun 503:2690-2697
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Xu, Benjamin Y; Penteado, Rafaella C; Weinreb, Robert N (2018) Diurnal Variation of Optical Coherence Tomography Measurements of Static and Dynamic Anterior Segment Parameters. J Glaucoma 27:16-21
Meshi, Amit; Chen, Kevin C; You, Qi Sheng et al. (2018) ANATOMICAL AND FUNCTIONAL TESTING IN DIABETIC PATIENTS WITHOUT RETINOPATHY: Results of Optical Coherence Tomography Angiography and Visual Acuity Under Varying Contrast and Luminance Conditions. Retina :
Suh, Min Hee; Zangwill, Linda M; Manalastas, Patricia Isabel C et al. (2018) Deep-Layer Microvasculature Dropout by Optical Coherence Tomography Angiography and Microstructure of Parapapillary Atrophy. Invest Ophthalmol Vis Sci 59:1995-2004

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