Abstract

Functional Vision Module The Functional Vision Module will provide the technologies required to interrogate visual function in experimental animals to the investigators involved in this P30 Core Grant for Vision Research. This module will provide state of the art assessment of visual function in mice and zebrafish. Included are visual electrophysiological assays such as the electroretinogram (ERG) and the visual evoked potential (VEP); and visual behavior assays such as the pupillary light reflex (PLR), the optokinetic reflex (OKR), optomotor reflex (OMR) and threshold measurement. Collectively, these assays interrogate visual function from light detection in the photoreceptors to signal integration and interpretation within the brain. Access to this core module will support NEI R01 funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1 funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY025585-05
Application #
10003325
Study Section
Special Emphasis Panel (ZEY1)
Project Start
2016-09-01
Project End
2021-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195

  Publications

Choi, Elliot H; Suh, Susie; Sander, Christopher L et al. (2018) Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet 27:2225-2243
Zhang, Lingjun; Li, Yan; Qiu, Wen et al. (2018) Targeting CD6 for the treatment of experimental autoimmune uveitis. J Autoimmun 90:84-93
Orban, Tivadar; Leinonen, Henri; Getter, Tamar et al. (2018) A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther 364:207-220
Zhao, Yue; Chundury, Rao V; Blandford, Alexander D et al. (2018) Anatomical Description of Zygomatic Foramina in African American Skulls. Ophthalmic Plast Reconstr Surg 34:168-171
Tarchick, Matthew J; Cutler, Alecia H; Trobenter, Timothy D et al. (2018) Endogenous insulin signaling in the RPE contributes to the maintenance of rod photoreceptor function in diabetes. Exp Eye Res 180:63-74
Kiser, Philip D; Zhang, Jianye; Sharma, Aditya et al. (2018) Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol 150:571-590
Blandford, Alexander D; Cherfan, Daniel G; Drake, Richard L et al. (2018) Continuous Positive Airway Pressure Thresholds for Nasolacrimal Air Regurgitation in a Cadaveric Model. Ophthalmic Plast Reconstr Surg 34:440-442
Medeiros, Carla S; Lassance, Luciana; Saikia, Paramananda et al. (2018) Posterior stromal cell apoptosis triggered by mechanical endothelial injury and basement membrane component nidogen-1 production in the cornea. Exp Eye Res 172:30-35
Kinoshita, Junzo; Peachey, Neal S (2018) Noninvasive Electroretinographic Procedures for the Study of the Mouse Retina. Curr Protoc Mouse Biol 8:1-16
Pollock, Lana M; Xie, Jing; Bell, Brent A et al. (2018) Retinoic acid signaling is essential for maintenance of the blood-retinal barrier. FASEB J 32:5674-5684

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