Abstract

The Nuclear Magnetic Resonance (NMR) Core with the existing state-of-the-art instrumentation and techniques is represents a critical part of COBRE to address the following needs of COBRE research programs across the campus ofthe University of Delaware (1) to facilitate the research and development of NMR spectroscopy as a premier method for structural analysis of a wide variety of systems in solution and solid states, and (2) to provide support for structural analyses of small-molecule and macromolecule-based biomaterials in solution and solid states.

Public Health Relevance

Structural characterization of biomaterials at atomic resolution is critical to the design and optimization of biomaterials. Nuclear Magnetic Resonance (NMR) spectroscopy plays a unique and an irreplaceable role as a method for atomic-scale structural analysis ofvarious kinds of materials. The NMR Core will provide stateof- the-art NMR research instrumentation and expertise to help COBRE investigators gain fundamental insights into the structures of materials under investigation. These studies will ultimately generate materials systems that are optimized for their targeted drug delivery and tissue engineering applications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM110758-01
Application #
8735398
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Project Start
Project End
Budget Start
2014-09-30
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$352,808
Indirect Cost
$126,649

  Institution

Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716

  Publications

Burch, Jason M; Mashayekh, Siavash; Wykoff, Dennis D et al. (2018) Bacterial Derived Carbohydrates Bind Cyr1 and Trigger Hyphal Growth in Candida albicans. ACS Infect Dis 4:53-58
O'Brien, Jessica G K; Chintala, Srinivasa R; Fox, Joseph M (2018) Stereoselective Synthesis of Bicyclo[6.1.0]nonene Precursors of the Bioorthogonal Reagents s-TCO and BCN. J Org Chem 83:7500-7503
McDonald, Nathan D; DeMeester, Kristen E; Lewis, Amanda L et al. (2018) Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide. J Biol Chem 293:19113-19126
Guan, Weiye; Liao, Jennie; Watson, Mary P (2018) Vinylation of Benzylic Amines via C-N Bond Functionalization of Benzylic Pyridinium Salts. Synthesis (Stuttg) 50:3231-3237
Hadden, Jodi A; Perilla, Juan R (2018) Molecular Dynamics Simulations of Protein-Drug Complexes: A Computational Protocol for Investigating the Interactions of Small-Molecule Therapeutics with Biological Targets and Biosensors. Methods Mol Biol 1762:245-270
Haider, Michael J; Zhang, Huixi Violet; Sinha, Nairiti et al. (2018) Self-assembly and soluble aggregate behavior of computationally designed coiled-coil peptide bundles. Soft Matter 14:5488-5496
Quinn, Caitlin M; Wang, Mingzhang; Fritz, Matthew P et al. (2018) Dynamic regulation of HIV-1 capsid interaction with the restriction factor TRIM5? identified by magic-angle spinning NMR and molecular dynamics simulations. Proc Natl Acad Sci U S A 115:11519-11524
Fang, Yinzhi; Zhang, Han; Huang, Zhen et al. (2018) Photochemical syntheses, transformations, and bioorthogonal chemistry of trans-cycloheptene and sila trans-cycloheptene Ag(i) complexes. Chem Sci 9:1953-1963
Potocny, Andrea M; Riley, Rachel S; O'Sullivan, Rachel K et al. (2018) Photochemotherapeutic Properties of a Linear Tetrapyrrole Palladium(II) Complex displaying an Exceptionally High Phototoxicity Index. Inorg Chem 57:10608-10615
Hadden, Jodi A; Perilla, Juan R; Schlicksup, Christopher John et al. (2018) All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits. Elife 7:

Showing the most recent 10 out of 177 publications