Abstract

The COBRE Center in Protein Structure and Function at The University of Kansas is overseen, operated, guided and driven by its Administrative Core. The required roles of Program Director/Principal Investigator, and also that of Program Coordinator, will be filled by Dr. Robert Hanzlik, who was the PD/PI throughout Phase I and Phase II of COBRE-PSF. He will be assisted and advised by a Leadership Committee consisting of the chairs of our three Core Lab Steering Committees (each of whom is a COBRE graduate) and the KU Associate Vice Chancellor for Research (who is also a chemist). An Internal Advisory Committee comprised of a senior faculty member from each of our three partner institutions (KSU, WSU and KUMC), and an External Advisory Committee comprised of four internationally recognized experts in protein structure and function, will also provide advice and guidance. The Administrative Core will implement and oversee a Pilot Project Program, a Writing Program, a Mentoring Program and three continuing and highly successful Core Labs in addition to providing overall leadership for the Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM110761-05
Application #
9520235
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Kansas Lawrence
Department
Type
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045

  Publications

Kyrychenko, Alexander; Lim, Nathan M; Vasquez-Montes, Victor et al. (2018) Refining Protein Penetration into the Lipid Bilayer Using Fluorescence Quenching and Molecular Dynamics Simulations: The Case of Diphtheria Toxin Translocation Domain. J Membr Biol 251:379-391
Damalanka, Vishnu C; Kim, Yunjeong; Galasiti Kankanamalage, Anushka C et al. (2018) Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease. Eur J Med Chem 143:881-890
Arnett, David C; Bailey, Sheila K; Johnson, Carey K (2018) Exploring the conformations of nitric oxide synthase with fluorescence. Front Biosci (Landmark Ed) 23:2133-2145
Galasiti Kankanamalage, Anushka C; Kim, Yunjeong; Damalanka, Vishnu C et al. (2018) Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. Eur J Med Chem 150:334-346
Lan, Lan; Liu, Hao; Smith, Amber R et al. (2018) Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins. BMC Cancer 18:809
Wu, Long; Zhang, Xin; Zhao, Liqin (2018) Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. J Neurosci 38:6665-6681
Haimov, Ora; Sehrawat, Urmila; Tamarkin-Ben Harush, Ana et al. (2018) Dynamic interactions of eIF4G1 with eIF4E and eIF1 underlie scanning dependent and independent translation. Mol Cell Biol :
Herrera, Alvaro I; Ploscariu, Nicoleta T; Geisbrecht, Brian V et al. (2018) 1H, 15N, and 13C resonance assignments of the third domain from the S. aureus innate immune evasion protein Eap. Biomol NMR Assign 12:175-178
Murakami, Ryo; Singh, Chingakham Ranjit; Morris, Jacob et al. (2018) The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation. Mol Cell Biol 38:
McGill, Jodi L; Kelly, Sean M; Kumar, Pankaj et al. (2018) Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf. Sci Rep 8:3021

Showing the most recent 10 out of 68 publications